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Our study provides a comprehensive multi‐omics profile of aging, integrating proteomic, metabolomic, and metagenomic analyses across diverse tissues and plasma. We identified the synergistic amplification of the circulating complement system and tissue‐wide immunoglobulin accumulation as key molecular drivers of inflammaging.
Feng Zhang+17 more
wiley +1 more source
Abstract Accurate kidney function assessment is essential for medication dosing, although traditional methods such as urine output and serum creatinine are limited, especially in patients with acute kidney injury. Cystatin C was made available as an alternative marker at our institution, prompting the formation of a multidisciplinary task force to ...
Victoria Williams+11 more
wiley +1 more source
Serum DCP may serve as an optimal biomarker for the diagnosis of HCC, but its accuracy appears to be influenced by liver function. The serum DCP may also serve as a biomarker for liver resection and interventional therapy of HCC, but is not promising for systemic treatment. ABSTRACT Background This retrospective multicenter study is aimed at evaluating
Hongying Bu+12 more
wiley +1 more source
Azygos and hepatic extraction of atrial natriuretic factor (ANF) in patients with cirrhosis [PDF]
Bendtsen, Flemming+2 more
core
The cytokeratin 18 (CK18) test has been served as the non‐invasive assessment to detect nonalcoholic steatohepatitis and fibrosis. We performed a meta‐analysis to evaluate the accuracy of CK18 against a liver biopsy in adults. Serum CK18 had moderate diagnostic value in different stages of liver fibrosis and significant inflammation, which may serve as
Jinwen Chen+6 more
wiley +1 more source
Clinical characteristics of patients with chronic hepatitis c infection at initial presentation to tertiary care in an Asian middle-income country [PDF]
Azzeri, Amirah+6 more
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Abstract Hypoxic‐ischemic encephalopathy (HIE) resulting from perinatal asphyxia presents a substantial risk of mortality and long‐term sequelae in neonates. Therapeutic hypothermia (TH) improves both short‐ and long‐term outcomes in near‐term/term neonates with moderate to severe HIE.
Zoë Vander Elst+10 more
wiley +1 more source
Liver resection for hepatocellular carcinoma in cirrhotics and noncirrhotics [PDF]
Grazi, Gian Luca
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The Lancet, 2021
Cirrhosis is widely prevalent worldwide and can be a consequence of different causes, such as obesity, non-alcoholic fatty liver disease, high alcohol consumption, hepatitis B or C infection, autoimmune diseases, cholestatic diseases, and iron or copper overload.
Pere Ginès+5 more
semanticscholar +4 more sources
Cirrhosis is widely prevalent worldwide and can be a consequence of different causes, such as obesity, non-alcoholic fatty liver disease, high alcohol consumption, hepatitis B or C infection, autoimmune diseases, cholestatic diseases, and iron or copper overload.
Pere Ginès+5 more
semanticscholar +4 more sources
Conversion of Micronodular Cirrhosis into Macronodular Cirrhosis [PDF]
The conversion from micro- to macronodular cirrhosis is claimed to be a general phenomenon. In this study, the conversion was quantitated by means of liver needle follow-up biopsies and autopsy in 156 patients followed in a controlled clinical trial of prednisone treatment in cirrhosis.
Hemming Poulsen+5 more
openaire +2 more sources