Results 321 to 330 of about 419,003 (365)

Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging

open access: yesiMeta, EarlyView.
Our study provides a comprehensive multi‐omics profile of aging, integrating proteomic, metabolomic, and metagenomic analyses across diverse tissues and plasma. We identified the synergistic amplification of the circulating complement system and tissue‐wide immunoglobulin accumulation as key molecular drivers of inflammaging.
Feng Zhang   +17 more
wiley   +1 more source

Implementing use of cystatin C‐guided estimated glomerular filtration rate for medication dosing at an Academic Medical Center

open access: yesJACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, EarlyView.
Abstract Accurate kidney function assessment is essential for medication dosing, although traditional methods such as urine output and serum creatinine are limited, especially in patients with acute kidney injury. Cystatin C was made available as an alternative marker at our institution, prompting the formation of a multidisciplinary task force to ...
Victoria Williams   +11 more
wiley   +1 more source

A Large‐Scale Retrospective Study of Serum Des‐Gamma‐Carboxy Prothrombin as a Diagnostic Marker of HCC: Effect of Liver Function on Specificity

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Serum DCP may serve as an optimal biomarker for the diagnosis of HCC, but its accuracy appears to be influenced by liver function. The serum DCP may also serve as a biomarker for liver resection and interventional therapy of HCC, but is not promising for systemic treatment. ABSTRACT Background This retrospective multicenter study is aimed at evaluating
Hongying Bu   +12 more
wiley   +1 more source

Azygos and hepatic extraction of atrial natriuretic factor (ANF) in patients with cirrhosis [PDF]

open access: yes, 1993
Bendtsen, Flemming   +2 more
core  

Diagnostic Value of Serum Cytokeratin 18 for the Staging of Liver Inflammation and Fibrosis: A Meta‐Analysis

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
The cytokeratin 18 (CK18) test has been served as the non‐invasive assessment to detect nonalcoholic steatohepatitis and fibrosis. We performed a meta‐analysis to evaluate the accuracy of CK18 against a liver biopsy in adults. Serum CK18 had moderate diagnostic value in different stages of liver fibrosis and significant inflammation, which may serve as
Jinwen Chen   +6 more
wiley   +1 more source

Clinical characteristics of patients with chronic hepatitis c infection at initial presentation to tertiary care in an Asian middle-income country [PDF]

open access: yes, 2018
Azzeri, Amirah   +6 more
core  

Mathematical Albumin Function for Neonates Undergoing Therapeutic Hypothermia in Comparison with Control Neonates

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Hypoxic‐ischemic encephalopathy (HIE) resulting from perinatal asphyxia presents a substantial risk of mortality and long‐term sequelae in neonates. Therapeutic hypothermia (TH) improves both short‐ and long‐term outcomes in near‐term/term neonates with moderate to severe HIE.
Zoë Vander Elst   +10 more
wiley   +1 more source

Liver cirrhosis

The Lancet, 2021
Cirrhosis is widely prevalent worldwide and can be a consequence of different causes, such as obesity, non-alcoholic fatty liver disease, high alcohol consumption, hepatitis B or C infection, autoimmune diseases, cholestatic diseases, and iron or copper overload.
Pere Ginès   +5 more
semanticscholar   +4 more sources

Conversion of Micronodular Cirrhosis into Macronodular Cirrhosis [PDF]

open access: possibleHepatology, 1983
The conversion from micro- to macronodular cirrhosis is claimed to be a general phenomenon. In this study, the conversion was quantitated by means of liver needle follow-up biopsies and autopsy in 156 patients followed in a controlled clinical trial of prednisone treatment in cirrhosis.
Hemming Poulsen   +5 more
openaire   +2 more sources

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