Results 321 to 330 of about 680,529 (391)

Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism

International Journal of Cancer, EarlyView.
Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello, Eric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti   +7 more
wiley   +1 more source

Liver-related outcomes in patients with cirrhosis: The value of clinical and laboratory data and noninvasive tests. [PDF]

PLoS One
Albhaisi S, Robinson A, Alsaadawi R, Sabo RT, Sanyal AJ.   +4 more
europepmc   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

In Vitro Assessment of Drug‐Induced Liver Injury Using Three‐Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Drug‐induced liver injury (DILI) is a serious adverse event and a common cause of postmarketing drug withdrawal. Despite nonclinical assessments of DILI risk, which are predominantly conducted in experimental animals, DILI remains a frequent adverse event, highlighting the need to improve nonclinical assessments.
Xingming Liu, Yuichiro Higuchi, Yuta Sakamoto, Shota Yanagida, Shotaro Uehara, Hiroshi Suemizu, Yasunari Kanda, Hiroyuki Kawagishi   +7 more
wiley   +1 more source

Association between the red blood cell distribution width-platelet ratio and the risk of in-hospital mortality in patients with alcoholic liver cirrhosis (with or without severe liver disease): a retrospective cohort study based on the MIMIC-IV database. [PDF]

BMJ Open
Dai J, Li B, Shui P, Xia B, Liu N.
europepmc   +1 more source

Pharmacokinetics and Safety of Fezolinetant in Women with Hepatic or Renal Impairment

The Journal of Clinical Pharmacology, EarlyView.
Abstract The neurokinin 3 receptor antagonist fezolinetant is an approved treatment for vasomotor symptoms due to menopause. The impacts of hepatic and renal impairment on the pharmacokinetics and safety of a single oral dose of fezolinetant 30 mg were investigated in two independent studies.
Megumi Iwai, Xuegong Wang, Melanie Patton, Lauren Benner, Nakyo Heo, Jace C. Nielsen, Anna Spence, Thomas C. Marbury, Jiayin Huang   +8 more
wiley   +1 more source

Cystatin C as a predictor of renal recovery and in hospital mortality in patients with acute kidney injury and liver cirrhosis. [PDF]

BMC Nephrol
Nagy E, Abdelfattah AH, Sayed-Ahmed N, Ahmed S.   +3 more
europepmc   +1 more source

Saliva as a TDM matrix and its application in the model‐informed precision dosing

The Journal of Clinical Pharmacology, EarlyView.
Abstract This study reviews the main points of saliva as a therapeutic drug monitoring (TDM) matrix, its advantages and limitations, the methods of saliva sample collection and testing, the types of drugs in saliva TDM, and the methods of establishing saliva population pharmacokinetic (Pop PK) models, as well as summarizes the experiences and ...
Baohua Xu, Yujie Wen, Jinxia Lu, Maobai Liu, Xin Luo, Wei Huang, Helin Xie, Yu Cheng, Hongqiang Qiu, Xuemei Wu   +9 more
wiley   +1 more source

The Heart of the Matter: A Case of Massive Pedal Edema Erroneously Attributed to Liver Cirrhosis. [PDF]

J Community Hosp Intern Med Perspect
Nekkanti A, Gopakumar H, Zainab K, Lynch T, Dhillon S.   +4 more
europepmc   +1 more source

Application of Two‐Dimensional Shear Wave Elastography in Evaluating Liver Reserve Function in Patients With Liver Cancer

Journal of Clinical Ultrasound, EarlyView.
ABSTRACT Background Shear wave elastography (SWE) is an emerging noninvasive imaging technique for assessing liver fibrosis. This meta‐analysis aimed to evaluate the diagnostic accuracy of SWE compared to conventional imaging techniques. Methods A systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science databases.
Bijuan Hu, Zhiping Huang, Liyin Huang
wiley   +1 more source