Results 141 to 150 of about 416,036 (340)

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source

Cisplatin and 5-fluorouracil infusion for metastatic colorectal carcinoma. Differences in survival in two patient groups with similar response rates [PDF]

, 1989
Nancy E. Kemeny, Donna Niedzwiecki, Bonnie Reichman, J F Botet, V. Vinciguerra, Richard A. Michaelson, Richard J. Rosenbluth, S. Deonarine   +7 more
openalex   +1 more source

Sympathetic Activation Promotes Kidney Fibrosis in Mice via Macrophage‐Derived N2ICD‐Enriched Extracellular Vesicles

Advanced Science, EarlyView.
Norepinephrine/α2B‐adrenoceptor axis promotes the secretion of Notch2 intracellular domain (N2ICD)‐enriched extracellular vesicles (EVs) from macrophages. These EVs deliver N2ICD into fibroblasts, thereby inducing their activation. Deletion of Notch2 or α2B‐AR in macrophages disrupts N2ICD‐enriched EV formation and alleviates kidney fibrosis in mice ...
Huiwen Ren, Yayan Hou, Chengsen Mu, Yinghong Zheng, Yuanyang Wang, Shumin Guo, Lu Wang, Wenlong Shang, Zhuming Yin, Cheng Dong, Yongsheng Chang, Bin Zhou, Renjie Chai, Ying Yu, Yujun Shen   +14 more
wiley   +1 more source

A Serum‐Stable Antimicrobial Peptide‐Based Delivery Platform for Selective Treatment of Nontargetable and Chemoresistant Tumors

Advanced Science, EarlyView.
A modular antimicrobial‐peptide‐based therapeutic system integrating membrane‐targeted selectivity, a conformation‐driven polyethylene glycolylated blocker, and serum‐stabilizing N‐cap is developed. The optimized conjugate 270 shows potent, rapid killing of the desired tumor cells, high serum stability, low off‐target toxicity, and broad applicability,
Tianxing Liu, Lingyu Ke, Ruize Sun, Xiaoling Chen, Mei Zhou, Olaf R. P. Bininda‐Emond, Chengbang Ma, Yangyang Jiang, Tao Wang, Chris Shaw, Lei Wang, Tianbao Chen, Alideertu Dong   +12 more
wiley   +1 more source

Effect of cisplatin on the plasma membrane phosphatase activities in ascites sarcoma-180 cells: a cytochemical study. [PDF]

, 1983
Shruti Aggarwal, I Niroomand-Rad
openalex   +1 more source

Restoring NK Cell Cytotoxicity Post‐Cryopreservation via Synthetic Cells

Advanced Science, EarlyView.
In this study, it is shown that 1‐day co‐culture with activated T cells or IL‐2‐presenting synthetic cells significantly enhances NK cell motility and cytotoxicity in 2D and 3D. Notably, synthetic cells restore the impaired cytotoxic function of cryopreserved NK and CAR‐NK cells in 3D.
Xiangda Zhou, Sijia Zhang, Wenjuan Yang, Susanne Gonder, Zeinab Sadjadi, Nils Piernitzki, Alina Moter, Shulagna Sharma, Anne Largeot, Nadja Küchler, Lea Kaschek, Gertrud Schäfer, Eva C. Schwarz, Hermann Eichler, Evelyn Ullrich, Heiko Rieger, Oskar Staufer, Jérôme Paggetti, Etienne Moussay, Markus Hoth, Bin Qu   +20 more
wiley   +1 more source

Relationship between chronological aging and acquired resistance to cisplatin in the yeast saccharomyces cerevisiae [PDF]

, 2019
The Sir2 gene is associated with an increase in longevity in yeasts, worms, flies and rodents. The human homolog, Sirt1, is also involved in longevity, by inhibiting cellular senescence.
Burgos-Molina, Antonio Manuel, Gil-Carmona, Luisa, Mercado-Sáenz, Silvia, Ruiz-Gomez, Miguel Jose   +3 more
core  

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

Lactate Activates the HCAR1/β‐Arrestin2/PP2A Signaling Axis to Mediate STAT1/2 Dephosphorylation and Drive Osteosarcoma Progression

Advanced Science, EarlyView.
In the present study, it is found that in osteosarcoma, lactate‐activated HCAR1 promotes β‐arrestin 2 translocation from cytoplasm to nucleus. In the nucleus, β‐arrestin 2 recruits PP2A to the activated STAT1/2 dimers, mediating STAT1/2 dephosphorylation and inhibiting the transcription of downstream anti‐oncogenes to promote OS progression.
Zhitao Han, Qi Jia, Guangjian Bai, Zhao Li, Jin Zeng, Zhenhua Wang, Jing Zhang, Jiashi Cao, Baoquan Xin, Yonggang Liu, Jingyu Shen, Lining Wang, Xing Huang, Chunlei Zhang, Kai Tong, Fenglei Dai, Yajie Zhang, Weina Zhu, Songyi Cheng, Yuanming Chen, Xinghai Yang, Guanghui Chen, Zhenhua Zhou, Yong Ma, Weibo Liu, Ting Wang, Tielong Liu   +26 more
wiley   +1 more source