Results 121 to 130 of about 553,677 (293)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Validation of Dynamic Natural Ventilation Protocols for Optimal Indoor Air Quality and Thermal Adaptive Comfort during the Winter Season in Subtropical-Climate School Buildings

open access: yesApplied Sciences
The need for energy-efficient buildings must be based on strong effective passive-design techniques, which coordinate indoor air quality and thermal comfort.
Antonio Sánchez Cordero   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The Human Being in Exposure to Mystery: Phenomenological Foundations of a Mystical Anthropology

open access: yesReligions
This article develops a phenomenological foundation of mystical anthropology through a dialogue between contemporary Spanish philosophy and the sixteenth-century Castilian mystical tradition.
Angélica Morales Arizmendi
doaj   +1 more source

Implementasi CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora) dalam Menangani Perdagangan Kukang Ilegal di Indonesia [PDF]

open access: yes, 2017
Slow loris or Nycticebus sp is one of endemic primate animals in Indonesia. Since 2007, slow loris has been categorized into Appendix I CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora).
Wahyadyatmika , Permana Adi
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Predicting the canopy conductance to water vapor of grapevines using a biophysical model in a hot and arid climate

open access: yesFrontiers in Plant Science
Canopy conductance is a crucial factor in modelling plant transpiration and is highly responsive to water stress. The objective of this study is to develop a straightforward method for estimating canopy conductance (gc) in grapevines. To predict gc, this
Ricardo Jorge Lopes Egipto   +2 more
doaj   +1 more source

Solar thermal heating and cooling. A bibliography with abstracts [PDF]

open access: yes
This bibliographic series cites and abstracts the literature and technical papers on the heating and cooling of buildings with solar thermal energy. Over 650 citations are arranged in the following categories: space heating and cooling systems; space ...
Arenson, M.
core   +1 more source

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