Results 111 to 120 of about 2,932,973 (293)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Lateral Condyle Impaction Fracture Reduction With Anterior Cruciate Ligament Reconstruction, Medial Collateral Ligament Reconstruction, and Repair of Lateral Meniscus Radial Tear After a High-Grade Pivot-Shift Injury

Arthroscopy Techniques
The pivot shift is a common injury mechanism during an anterior cruciate ligament injury in which the tibia rotates anterolaterally with a combined valgus force. This mechanism can lead to bone bruising and even impaction fractures of the lateral femoral
Luke V. Tollefson, B.S., Evan P. Shoemaker, B.A., Nathan J. Jacobson, M.D., Erik L. Slette, M.D., Robert F. LaPrade, M.D., Ph.D.   +4 more
doaj   +1 more source

Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment

Arthritis Care &Research, EarlyView.
Objective Lupus nephritis (LN) management remains challenging, and novel noninvasive biomarkers are needed. This study quantified serum soluble mediators in the Accelerating Medicines Partnership (AMP) LN cohort to identify biomarkers of histologic features and treatment response.
Andrea Fava, Catriona A. Wagner, Carla J. Guthridge, Susan Macwana, Wade DeJager, Melissa E. Munroe, Peter Izmirly, H. Michael Belmont, Betty Diamond, Anne Davidson, Paul J. Utz, Michael H. Weisman, Philip M. Carlucci, Maria Dall'Era, Kenneth Kalunian, Chaim Putterman, Jennifer Anolik, Jennifer L. Barnas, David Wofsy, Diane Kamen, Richard A. Furie, Deepak A. Rao, the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus Network, Chun‐Hao Lee, Derek Fine, Manny Monroy‐Trujillo, Ummara Shah, Mariko Ishimori, Robert M. Clancy, Michael Belmont, Ming Wu, Nicole Bornkamp, Evan Der, Beatrice Goilav, Nicole Jordan, Daniel Schwartz, James Pullman, David Wofsy, Dawn Smilek, Patti Tosta, Matthias Kretzler, Celine C. Berthier, E. Steve Woodle, Dave Hildeman, Michael Brenner, Michelle Petri, Joel M. Guthridge, Jill Buyon, Judith A. James   +48 more
wiley   +1 more source

The Prosecutor and the Press: Lessons (Not) Learned from the Mike Nifong Debacle [PDF]

, 2008
Current projections indicate that by 2050, two in every three people will live in urban areas, and that cities will accommodate 3 billion people during this period. Cities are consuming three-quarters of the world's energy and causing three-quarters of
Cassidy, R. Michael
core   +2 more sources

A high efficiency precision genome editing method with CRISPR in iPSCs

Scientific Reports
The use of genetic engineering to generate point mutations in induced pluripotent stem cells (iPSCs) is essential for studying a specific genetic effect in an isogenic background. We demonstrate that a combination of p53 inhibition and pro-survival small
Avinash Singh, G. Dalton Smedley, Jamee-Grace Rose, Kristina Fredriksen, Ying Zhang, Ling Li, Shauna H. Yuan   +6 more
doaj   +1 more source

Isolated Osteochondral Autograft Transplantation for a Focal Chondral Defect of the Patella

Arthroscopy Techniques
Patellar chondral lesions are disabling injuries that are mechanically limiting and lead to the further progression of osteoarthritis. Patellar chondral lesions are identified in 11.0% to 34.6% of routine knee arthroscopies.
Evan P. Shoemaker, B.A., Luke V. Tollefson, B.S., Matthew T. Rasmussen, M.D., Dustin R. Lee, M.D., Robert F. LaPrade, M.D., Ph.D.   +4 more
doaj   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Superstar Cities [PDF]

Differences in house price and income growth rates between 1950 and 2000 across metropolitan areas have led to an ever-widening gap in housing values and incomes between the typical and highest-priced locations.
Christopher Mayer, Joseph Gyourko, Todd Sinai   +2 more
core  

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, EarlyView.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

High Streets for all. [PDF]

, 2017
This study takes one of the most commonplace and everyday experiences of the city – the high street – and explores its social value from the perspective of Londoners.
LSE Cities, Suzanne Mary, We Made That,
core