Results 101 to 110 of about 11,841,025 (403)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

HOW TO DESIGN A REPRESENTATIVE LOGO FOR A CITY

open access: yesJournal of Industrial Design and Engineering Graphics, 2019
It is not easy to create a logo, as identity graphic representation for a city. It is a work of study and graphics, using many information about the theme. And, of course, symbols, signs and colours to convey an interesting message to the people.
Nicoleta - Elisabeta Pascu   +3 more
doaj  

Old Cities, New Cities, No Cities [PDF]

open access: yesScience, 1972
Glenn T. Seaborg, William R. Corliss
openaire   +2 more sources

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

open access: yesAging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath   +3 more
wiley   +1 more source

Ground-Level Ozone: Smog City [PDF]

open access: yes
This lesson provides an introduction to the problems associated with ground-level ozone ('smog'). It reinforces the idea that ozone at ground level is harmful while that in the upper atmosphere has a beneficial effect.
Matt Laposata
core  

City-regionalism as a politics of collective provision : regional transport infrastructure in Denver, USA [PDF]

open access: yes, 2013
The rise of the city-region concept has focused attention on the nature of territorial politics underpinning city-regionalism. This paper investigates the relationship between territorial politics, city-regionalism and the collective provision of mass ...
Bhattacharjee, Sutapa   +2 more
core   +2 more sources

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

open access: yesAging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst   +4 more
wiley   +1 more source

Deconstructing the symbolic city:Jerome as guide to late antique Rome [PDF]

open access: yes, 2012
This article considers the writings of Saint Jerome as a source for writing a cultural history of the city of Rome in late antiquity. Jerome is of course, in many respects, an unreliable witness but his lively and often conflicted accounts of the city do
Grig, Lucy
core   +1 more source

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