Results 81 to 90 of about 11,841,025 (403)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
ROAD FREIGHT TRANSPORT IN THE CITY
Nauka ta progres transportu, 2008 The paper is dealt with the issues related to the organization of traffic of truck transport in logistic system of a city. The purpose of paper is consideration of the basic problems concerning the city traffic.
O. M. Horyainov, Yu. V. Buhaiev
doaj
The wolf and the city: insights on wolves' conservation in the anthropocene [PDF]
, 2023 Michele Zanni +3 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
La ville revisitée par les sportifs... ?
Territoire en Mouvement, 2006 The appearance of new sports practices during the 70’s caused induced effects like a sportivisation of the society and a diversification of the practices places, in particular with urban spaces that the sport adopted (streets, car parks, etc.).
Christian Dorvillé, Claude Sobry
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Sharing Cities Shaping Cities [PDF]
, 2019 In recent years, ‘sharing cities’ has spread globally, starting in 2012 when Seoul declared its intent to pursue sharing economy strategies [1]. Other cities then followed, including Amsterdam, Boulder, and Rio de Janeiro. Their pursuits to become sharing cities also intended to face major contemporary urban challenges, including global urbanization [2]
Arcidiacono, Andrea +2 more
openaire +4 more sources
The city as a refuge for insect pollinators
Conservation Biology, 2017 Research on urban insect pollinators is changing views on the biological value and ecological importance of cities. The abundance and diversity of native bee species in urban landscapes that are absent in nearby rural lands evidence the biological value ...
Damon M. Hall +22 more
semanticscholar +1 more source
University-Campus-Based Zero-Carbon Action Plans for Accelerating the Zero-Carbon City Transition [PDF]
, 2023 Md. Salman Islam +5 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source