Results 61 to 70 of about 3,723,147 (290)

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

open access: yesAdvanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

The Sillyon main city gate

open access: yes, 2018
Sillyon’s Main City Gate is a structure situated in the southwest part of the city. It consists of a complex with a courtyard entry gate and two towers. It is called the “Main City Gate” because it is the largest known gate of Sillyon and because it is the only entrance that allow both pedestrian and vehicular traffic.
Taşkıran, Murat, Özer, Elif
openaire   +5 more sources

Research on methane emission characteristics of city gate stations based on field measurements

open access: yes管道保护
This study aims to clarify the methane emission characteristics and influencing factors at city gate stations. Using the High Flow Sampler (Hi-Flow) method, component-level methane emissions were measured on-site at 11 typical city gate stations ...
Peng WANG   +4 more
doaj   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

open access: yesAdvanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao   +12 more
wiley   +1 more source

The Lion Gate, Hattusa

open access: yes, 2015
The Lion Gate in the south-west of Hattusa. At Hattuša, the capital city of Hittites (today in the Çorum Province, Turkey) from their beginning in the 17th century BC until the collapse of the empire in early 12th century BC. By the 12th century the city
Gonnet-Bağana, Hatice
core   +5 more sources

Multi‐Dimensional Physical‐Layer Security via Digitally Mediated Space–Time Modulation

open access: yesAdvanced Science, EarlyView.
Digitally mediated space–time modulation moves radiation control beyond hardware‐bound switching. Multiple information‐bearing and masking waveforms are jointly synthesized at baseband and coherently coupled to simple periodic time modulation, enabling programmable, independently directed multi‐beam radiation without increasing switching‐state ...
Kejin Chen   +8 more
wiley   +1 more source

Mimicking Life: Autonomous Oscillating Artificial Cilia Driven by Chemical Power

open access: yesAdvanced Intelligent Systems
Cilia are filamentous organelles that carry out functions critical for life, including fluid transport and locomotion. Given their importance, artificial cilia have been developed to mimic natural ones.
Rajata Suvra Chakrovorty   +2 more
doaj   +1 more source

Marseille as Privatopia The Collapsing City, the Gated City

open access: yes, 2023
Au cours des 25 dernières années, l'effet " sun belt ", la hausse des prix de l'immobilier et la spéculation foncière ont accentué l'étalement urbain de Marseille vers le littoral et les espaces naturels des calanques et collines qui entourent la ville.
openaire   +2 more sources

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

open access: yesAdvanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang   +18 more
wiley   +1 more source

Chemical Modification Strategies for Therapeutic Oligonucleotides: Mechanism Compatibility, Design Trade-Offs, and Translational Barriers

open access: yesMolecules
Oligonucleotide therapeutics represent an expanding class of medicines that can regulate gene expression, RNA processing, protein translation, immune signaling, and biomolecular recognition through sequence-specific or structure-dependent mechanisms ...
Kameron Burton, Kristen Dellinger
doaj   +1 more source

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