Results 61 to 70 of about 27,614 (267)

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Application of Gum Arabic on the Geotechnical Properties of Subgrade Materials

Acta Technica Jaurinensis
This study investigates the impact of Gum Arabic on the geotechnical properties of subgrade soil materials, a non-traditional soil stabilization technique.
Wasiu O. Ajagbe, Adebola S. Akolade, Oluwatosin D. Ogunlade, Precious A. Olaomotito, Itunu D. Odunewu, Oluwaseyi O. Alabi   +5 more
doaj   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Mimicking Life: Autonomous Oscillating Artificial Cilia Driven by Chemical Power

Advanced Intelligent Systems
Cilia are filamentous organelles that carry out functions critical for life, including fluid transport and locomotion. Given their importance, artificial cilia have been developed to mimic natural ones.
Rajata Suvra Chakrovorty, Yaqeen Salatneh Ashqer, Suzanne Ahmed   +2 more
doaj   +1 more source

Ion Superhighways in a Hierarchical Polymer‐Ceramic Membrane Enable Rapid and Selective Lithium Extraction

Advanced Science, EarlyView.
A flexible PDMS‐LATP polymer‐ceramic membrane creates lithium‐ion “superhighways” for rapid and selective extraction from complex brines. The amorphous PDMS matrix suppresses nonselective leakage and stabilizes the ceramic network, while LATP provides preferential Li+ conduction.
Xinxin Wei, Jiawei Sun, Min Wei Boey, Xiaolu Li, Minji Kim, Junghwan Kim, Hongjiang Chen, Patrick H.‐L. Sit, Yixiang Wang, Zhigang Li, Ze‐Xian Low, Jason Chun‐Ho Lam, Alicia Kyoungjin An   +12 more
wiley   +1 more source

Space‐Time Metasurface Antenna Enabled High‐Dimensional Electromagnetic Modulation for Intrinsic Physical Layer Security

Advanced Science, EarlyView.
The concept of high‐dimensional EM modulation using the STMA for physical layer secure communication is illustrated in figure. The STMA consists of a series of programmable unit cells, with 1‐bit reconfigurable phase states (0/π). The STMA is excited by a monochromatic continuous wave (CW) at frequency fc and controlled by a field‐programmable gate ...
Xinyu Fang, Yiqing Sun, Chenfeng Yang, Siran Wang, Zheng Xing Wang, Kaixu Wang, Geng‐Bo Wu   +6 more
wiley   +1 more source

Novel Loss Functions for Improved Data Visualization in t-SNE

Machine Learning and Knowledge Extraction
A popular method for projecting high-dimensional data onto a lower-dimensional space while preserving the integrity of its structure is t-distributed Stochastic Neighbor Embedding (t-SNE).
Sara Nassar, Rachid Hedjam, Samir Brahim Belhaouari   +2 more
doaj   +1 more source

Stepwise Engineering of Van der Waals Heterostructures for High Current Density in Light Emitting Devices

Advanced Electronic Materials, EarlyView.
A novel strategy for achieving high current density in van der Waals (vdW) heterostructure‐based light‐emitting devices (LEDs) is proposed. Based on this concept, an LED utilizing a WS2/WSe2 heterostructure was fabricated, achieving a current density of 9.4 × 104 A/cm2.
Rei Usami, Koshi Oi, Keisuke Yamada, Jiang Pu, Hao Ou, Takahiko Endo, Yasumitsu Miyata, Taishi Takenobu   +7 more
wiley   +1 more source

High entropy oxides: New superior supports for single atom catalysts

Next Materials
Single Atom catalyst (SAC), a new frontier in heterogeneous catalyst design has evolved as a novel strategy to resolve the cost puzzle hindering the commercial scale applications of benchmark noble metal catalysts in various technologies.
Panesun Tukur, Frank Tukur, Yirong Mo, Qiangu Yan, Chaochao Dun, Jianjun Wei   +5 more
doaj   +1 more source