Results 41 to 50 of about 509,348 (263)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Le voyage à Alger dans les guides touristiques français au XXe siècle
Diacronie. Studi di Storia Contemporanea, 2018 To what extent touristic guides allow us to study the encounter between French tourists and Algiers, French colonial jewel? Guides are precious sources to contribute to the cultural history of French Algeria.
Sihem Bella est agrégée d’histoire et diplômée de Sciences Po (Paris) en histoire contemporaine. Ses recherches portent sur l’histoire culturelle de l’Algérie coloniale, plus spécifiquement l’histoire du voyage et du tourisme.
doaj
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Functioning of the English tourism terminology in the guides to Ukraine
Записки з романо-германської філології, 2015 The article outlines main aspects of study of English tourism terminology, in particular, functional. General specific features of English guides and peculiarities of tourism terms functioning in them have been reviewed in the article. Attempted analysis
В. В. Прима
doaj +1 more source
Peran Guru Terhadap Kebersihan Mulut Dan Gigi Pada Anak Usia Dini Di RA Al Aziziyah Kota Bekasi
Wisdom: Jurnal Pendidikan Anak Usia Dini, 2022 Dental health in early childhood needs attention and counseling efforts in maintaining oral and dental hygiene. One way to treat dental health in early childhood at school is to brush their teeth properly and thoroughly will help children maintain good ...
Cut Rosmawati
doaj +1 more source
Farm Fresh Foods: What to Know About Growing and Selling Produce in Buffalo [PDF]
, 2018 It details local regulations on market and community gardens as well as rules for selling produce. It includes tips to find the right locations to plant food gardens and opportunities for education on growing and selling.
Roberts, Colleen
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
New record of the snapping shrimp Alpheus edwardsii (Audouin, 1826) (Crustacea: Alpheoidea) in Basrah, Iraq [PDF]
Arthropods, 2017 Specimens of the snapping shrimp Alpheus edwardsii, were collected from the intertidal zone of Faw and Shatt Al-Basrah channel in Basrah city, Iraq during October 2016. Photographs by digital camera and measurements were presented.
Tariq H. Y. Al-Maliky +2 more
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A Model for Improving the Performance of Tourist Guides (Case Study: Tehran City) [PDF]
گردشگری و اوقات فراغتThe performance of professional guides plays the key role in the tourism experience success; therefore, its improvement is considered as one of the tourism organizations concerns, and by identifying and paying attention to the performance dimensions and ...
Diana Kodsieh, Ismael Ghaderi
doaj +1 more source
Revista Conjuntura Austral, 2021 This article aims to discuss how Marielle Franco’s symbolism can contribute to the theoretical transformation of International Relations (IR). Therefore, we will reflect on the political trajectory of Marielle Franco, a black woman, LGBTQIA+, sociologist,
Mariana Felix Quadros +2 more
doaj +1 more source