Results 51 to 60 of about 1,661,390 (347)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The aesthetics of the city–image [PDF]
, 2015 In this paper, I will examine the aesthetic implications of the theories which regard the city as an image. Essentially, I will focus on the positions of the two practitioners, Kevin Lynch and Juhani Pallasmaa, who are an urban planner and an architect ...
Popczyk, Maria
core +2 more sources
Location recognition over large time lags [PDF]
, 2015 Would it be possible to automatically associate ancient pictures to modern ones and create fancy cultural heritage city maps? We introduce here the task of recognizing the location depicted in an old photo given modern annotated images collected from the
Fernando, Basura +2 more
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Evaluating News In Press About Konya In Context Of City Image
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2014 Within the globalizing world, competition increased among cities and therefore they started to give more importance to be more differentiated ones among thousands of their competitors.
Nur Görkemli, Başak Solmaz
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RUDN Journal of Russian HistoryThe author examines the evolution of St. Petersburg and Moscow, the Russian capitals, into megacities under the influence of industrialization in the second half of the XIX century. The urbanization processes in these cities and the challenges they faced
Alexander P. Shevyrev
doaj +1 more source
Modern Urban Culture: a City for or against a Person?
Дискурс, 2020 Introduction. The paper attempts to find answers to the questions: will it be possible to preserve historical-cultural “face” of the city, or it will disappear under the onslaught of the advanced achievements of civilization; is there an urban space to a
O. V. Kireeva, M. N. Veselova
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
MENTAL REPRESENTATION OF KAZAN CITY IMAGE
Архитектон, 2021 The article discusses methods of city image definition and presents the results of an empirical study on mental representation of Kazan carried out by methods of mental mapping, in-depth interviewing, questionnaires and GIS data analysis.
Latypova Maria S. +1 more
doaj +1 more source
Dublin City University at CLEF 2004: experiments with the ImageCLEF St Andrew's collection [PDF]
, 2004 For the CLEF 2004 ImageCLEF St Andrew's Collection task the Dublin City University group carried out three sets of experiments: standard cross-language information retrieval (CLIR) runs using topic translation via machine translation (MT), combination ...
Groves, Declan +5 more
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