Results 61 to 70 of about 1,661,390 (347)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Internal and External Collaborative Shaping: The Role of Official Information and Online Communities in Shaping a City’s Image

Land
City image is essential for city marketing, yet the impact of “outside–in” shaping by social media in the Web 2.0 era has been largely overlooked.
Yuxuan Tian, Desheng Xue, Chen Liu, Yubin Ou   +3 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Remote sensing and interdisciplinary approach for studying Dubai’s urban context and development [PDF]

, 2016
Outlining the different phases and features of the urban and socio-economic development of Dubai, this work is aimed at highlighting the potential of remote sensing and the interdisciplinary approach for the study of cities characterised by overwhelming ...
DE VECCHIS, Gino, Fea, Maurizio, Pesaresi, Cristiano   +2 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Translocal imagination of Hong Kong connections: the shifting of Chow Yun-Fat's star image since 1997 [PDF]

, 2014
Anyone who is interested in Hong Kong cinema must be familiar with one name: Chow Yun-fat (b. 1955). He rose to film stardom in the 1980s when Hong Kong cinema started to attract global attention beyond East Asia.
A Fuqua, Entgroup, Foreign Affairs, Defense, and Trade Division, G Marchetti, J Foley, J Schwaz, J Stringer, K-C Lo, L Sun, L Sun, M Cheung, M Rance, NK Denzin, P Hunter, S Fore, S Kei, S Yu, T Zhu, X Guo, X Lin, Y Gao, Y Zheng   +21 more
core   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The image of voivodeship cities among residents: exploring age-related perspectives

Economics and Environment
Purpose: Image is one of the key issues in city marketing and branding. City image studies are essential tools for urban planners, social researchers as well as political decision-makers and local authorities aiming to understand how people perceive the
Ewelina Tomaszewska, Ewa Glińska
doaj   +1 more source

Surviving urban renewal program: Case study of a traditional urban village in Kuala Lumpur [PDF]

, 2010
The study undertakes an analysis of the development trajectory and outcomes of a 110 years Malay village located within Kuala Lumpur, Malaysia called Kampung Baru.
Alhabshi, Sharifah Mariam
core