Results 181 to 190 of about 180,987 (265)

5G/6G Networks for Wireless Communication and IoT. [PDF]

Sensors (Basel)
Suraci C, Araniti G.
europepmc   +1 more source

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

Advanced Science, EarlyView.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen, Ming‐Ying Xiao, Lan‐Lan Guo, Hao‐Yue Hu, Sui‐Xian Zhang, Bai‐Qiang Dong, Chen‐Fei Wu, Xia‐Hang Huang, Li Li, Run‐Zhe Chen, Yuan‐Yang Huang, Ying Jin, Hai Song, Ying Wang, Qi‐Wen Li, Ming Chen, Xuan Li, Yuan‐Yuan Chen   +17 more
wiley   +1 more source

LiquidGAN for Handwriting-Based Detection and Severity Classification of Extrapyramidal Symptoms. [PDF]

Sensors (Basel)
Liyanage EM, Lee CH, Chang WY, Lee AA, Liaw GH, Yang WC, Liu YH, Lan KC, Ling SH.   +8 more
europepmc   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Energy-aware latency minimization in multi-source spatiotemporal data fusion for IoT networks. [PDF]

Sci Rep
Alsharif MH, Kumar A, Manna S, Saxena V, Khan S, Koondhar MA, Saeed S, Alsharif NHM.   +7 more
europepmc   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Topological structure and influencing factors of the spatial CO₂ emission network in Chinese cities. [PDF]

Sci Rep
Yang F, Zhang X, Wang N, Zuo S, Yang M.
europepmc   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Transmission of rifampicin-resistant tuberculosis in Ho Chi Minh City, Viet Nam: a prospective genomic epidemiology study

Spies R, Hanh NH, Phu PT, Lan LK, Lan K, Hue NN, Quang NL, Thu DDA, Huong NTL, Thao TLTN, Tram TTB, Ha VTN, Ha DTM, Lan NH, Hai NP, Thuan NH, Quy TTK, Dreyer V, Niemann S, Crook D, Van LH, Thwaites G, Thuong NTT, Choisy M, Watson J, Walker T.   +25 more
europepmc   +1 more source

Optimization of broadband metamaterial absorber using twin delayed deep deterministic policy gradient reinforcement learning technique. [PDF]

Sci Rep
Mahmoud BE, Ali TA, Obayya SSA, Hameed MFO.   +3 more
europepmc   +1 more source