Results 281 to 290 of about 2,059,614 (360)

Mechanism of Lenvatinib Resistance via Exosomal miRNA‐132/Nrf2 Axis in Hepatocellular Carcinoma

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Exosomal miRNA‐132 from LVT‐res HCC cells activated Nrf2 expression through the PTEN/GSK3β pathway in recipient cells. This cascade could induce drug resistance in non‐resistant HCC cells in the TME. ABSTRACT Introduction Lenvatinib is a multiple receptor tyrosine kinase inhibitor and a first‐line targeted therapy for hepatocellular carcinoma (HCC ...
Chie Takasu   +7 more
wiley   +1 more source

Immediate Reconstruction of Pancretaticogastrostomy Following Hepatopancreatoduodenectomy for Biliary Tact Cancer: A Single‐Center Review of 33 Consecutive Patients

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This study showed that the pancreaticogastrostomy technique in HPD of biliary tract cancer reduced the incidence of pancreatic fistula from 45% to 12%. In‐hospital mortality was also reduced from 27% to 3%. ABSTRACT Background and Purpose Although hepatopancreaticoduodenectomy (HPD) is effective for margin‐negative curative resection of biliary tract ...
Ryusei Matsuyama   +9 more
wiley   +1 more source

Frailty Recovery Following Minimally Invasive Surgery: An Emerging Perspective on Surgical Benefits in Elderly Colorectal Cancer Patients

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This prospective study investigated the impact of MIS on frailty and outcomes in elderly CRC patients. While frail patients showed lower OS, MIS was safely performed. Among recurrence‐free patients, frailty status improved at 1 year, suggesting that curative surgery may offer not only oncologic benefits but also potential for frailty improvement ...
Hajime Ushigome   +9 more
wiley   +1 more source

Internet of Things‐Based Framework Application at a University Campus Scale: Linking Smart Monitoring Systems and Stormwater Management

open access: yesAdvanced Intelligent Discovery, EarlyView.
This study presents an Internet of Things‐based stormwater monitoring framework piloted at the University of Maryland campus to support Municipal Separate Stormwater Sewer System compliance and adaptive planning. Developed with key campus stakeholders, the framework integrates real‐time sensor deployment, data‐informed insights on runoff and water ...
Qianyao Si   +16 more
wiley   +1 more source

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