Results 141 to 150 of about 1,044,599 (317)

Big city life? Challenges and trade-offs for Auckland city [PDF]

, 2014
Priming Auckland for ambitious future growth requires change on many policy fronts. Auckland is starting to swell. Rapid population and income growth are occurring, but Auckland’s narrow geography – with harbours on both sides of the city – limits land ...
Kirdan Lees
core  

Long-term health conditions in UK working-age adults: a cross-sectional analysis of associations with demographic, socioeconomic, psychosocial and health-related factors in an inner-city population. [PDF]

BMJ Open, 2022
Stagg AL, Hatch S, Fear NT, Dorrington S, Madan I, Stevelink SAM.   +5 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Procalcitonin Levels in COVID-19 Patients Are Strongly Associated with Mortality and ICU Acceptance in an Underserved, Inner City Population. [PDF]

Medicina (Kaunas), 2021
Feng T, James A, Doumlele K, White S, Twardzik W, Zahid K, Sattar Z, Ukponmwan O, Nakeshbandi M, Chow L, Foronjy R.   +10 more
europepmc   +1 more source

A Rare Allele of ST5 From Wild Rice Enhances Salt Tolerance in Rice

Advanced Science, EarlyView.
A novel salt‐tolerance gene ST5W, characterized by a unique 36‐bp promoter insertion, is found exclusively in a small subset of Oryza rufipogon and is absent in cultivated rice. Field trials confirm ST5W significantly enhances rice yield across diverse genetic backgrounds under saline conditions.
Meng Xing, Jingfen Huang, Qiaoling Yuan, Ziyi Yang, Yanyan Wang, Mingchao Zhao, Yamin Nie, Rui Xu, Hongge Qian, Wenxi Chen, Qiaoling Zhang, Qi Du, Leiyue Geng, Yapeng Li, Ziyi Chen, Shizhuang Wang, Like Lou, Haiyuan Peng, Chongke Zheng, Xianzhi Xie, Xiaoming Zheng, Lifang Zhang, Lianguang Shang, Jiaqiang Sun, Qian Qian, Qingwen Yang, Weihua Qiao   +26 more
wiley   +1 more source

Post-processing methods for mitigating algorithmic bias in healthcare classification models: An extended umbrella review

BMC Digital Health
Background AI and predictive analytics have increased the speed of innovation in medicine. If left unchecked, however, algorithmic bias can exacerbate health disparities across race, class, or gender.
Shaina Mackin, Vincent J. Major, Rumi Chunara, Remle Newton-Dame   +3 more
doaj   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Population, 258,447, Jan. 1,1934, City of Toledo, Ohio, 1933

This map shows the United States Census Bureau tracts of 1930 in Toledo, Ohio. Information was prepared under the direction of the Toledo City Plan Commission and collected by the Federal Emergency Relief Administration.
United States. Federal Emergency Relief Administration
core  

Population Projections for the City of Rajneeshpuram, Oregon, 1982 - 2002

, 1982
The projections found within this report are an attempt to model population growth in a manner consistent with the expected economic development of the City of Rajneeshpuram.
Population Research Center, Portland State University
core  

Identifying and mitigating algorithmic bias in the safety net

npj Digital Medicine
Algorithmic bias occurs when predictive model performance varies meaningfully across sociodemographic classes, exacerbating systemic healthcare disparities.
Shaina Mackin, Vincent J. Major, Rumi Chunara, Remle Newton-Dame   +3 more
doaj   +1 more source