Results 191 to 200 of about 1,316,499 (288)

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai, Shriarjun Shastry, Morgan R. Hurst, Arianna Minzoni, Eduardo Barbieri, Luke Remmler, Eugene N. Muratov, Michael A. Daniele, Stefano Menegatti, Alexander Tropsha   +9 more
wiley   +1 more source

Degradation Mechanism of Mechanical Properties of Concrete in a High Hydraulic Pressure Environment. [PDF]

Materials (Basel)
Du J, Zhang X, Xia Y, Ji Y.
europepmc   +1 more source

Influence of Zn2+ and Oxygen Supply on Malic Acid Production and Growth of Aspergillus oryzae

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Malic acid is a valuable platform chemical traditionally derived from fossil‐based resources. Microbial cultivation with Aspergillus oryzae offers a sustainable alternative based on renewable feedstocks. In this study, a well‐established minimal medium for malic acid production, commonly used in previous research to ensure reproducibility, was
Lukas Hartmann, Anke Neumann, Dirk Holtmann, Katrin Ochsenreither   +3 more
wiley   +1 more source

Influence of nickel doping on the moisture adsorption properties of magnesium aluminate spinel: thermodynamic and kinetic analysis. [PDF]

RSC Adv
Saleem A, Hassan R, Ehtisham M, Almatawa MS, Badawi AK, Ismail B.   +5 more
europepmc   +1 more source

Development of Raman Spectroscopy and Machine Learning Methods for Protein Aggregate Quantification: Application to BSA in Chromatographic Processes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein aggregation poses a significant risk to biopharmaceutical product quality, as even minor amounts of oligomeric species can compromise efficacy and safety. Rapid and reliable detection of protein aggregates thus remains a major challenge in biopharmaceutical manufacturing.
Jakob Heyer‐Müller, Robin Schiemer, Lars Robbel, Michael Schmitt, Jürgen Hubbuch   +4 more
wiley   +1 more source

Investigating the Triaxial Mechanical Behaviour of Silicone Rubber Material. [PDF]

Polymers (Basel)
Yang J, Chen N, Gao J, Wang Y, Long S, Yao X, Wu Z, Zhao J.   +7 more
europepmc   +1 more source

High Yield Branched Puromycin Linker Design Enables Efficient cDNA Display and Chemical Modification of Peptides

Biotechnology and Bioengineering, EarlyView.
A novel puromycin linker for cDNA display was synthesized via SPAAC reaction. Its functionality was confirmed by recovering intact DNA after selection against EpCAM. The system also enabled the verification of bicyclic peptides during display, demonstrating its utility for constructing and screening structurally complex peptide libraries.
Simon Schneider, Melanie Boll, Matthias Eder, Ann‐Christin Eder   +3 more
wiley   +1 more source

Dilatant Failure States for Drained Triaxial Compression of Some Geomaterials. [PDF]

Materials (Basel)
Szypcio Z, Dołżyk-Szypcio K, Gabryś K, Sas W.   +3 more
europepmc   +1 more source

Gaussian Processes for Predictive QSAR Modeling of Chromatographic Processes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chromatography is a key unit operation in the biopharmaceutical manufacturing process used for protein purification and polishing. Design and optimization of these processes are resource‐intensive resulting from the complex combinatorial design space.
Harini Narayanan, Douglas Nolan, Lijuan Li, Edward King, Andrew Fiordalis, David Benjamin Nickel, George Parks, J. Christopher Love   +7 more
wiley   +1 more source

Layer Bond Strength in 3D-Printed Concrete: The Role of Interlayer Surface Area and Printing Delay Time. [PDF]

Materials (Basel)
Žižková N, Válek J, Vespalec A, Melichar J, Czarnecki S, Chajec A.   +5 more
europepmc   +1 more source