Results 131 to 140 of about 8,108,558 (288)

Model‐Driven Monitoring and Parameter‐Based Development of an Escherichia coli Fed‐Batch Process for Production of a Fab Antibody Fragment Across Scales

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg   +8 more
wiley   +1 more source

Low‐Field MRI as a Multiparametric Tool for Large Engineered Tissue Characterization

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Advances in 3D bioprinting have enabled the fabrication of large and complex engineered tissues, but their increasing size demands non‐invasive tools for monitoring structure, maturation, and perfusion. Magnetic Resonance Imaging (MRI) offers unique multiparametric capabilities, yet high‐field systems remain costly and inaccessible for most ...
Yilbert Gimenez   +8 more
wiley   +1 more source

Civil Law: Future prospects

open access: yesThēmis, 2014
Civil Law is the kind of figure that everybody knows about, but only a few understand. It is considered a basic legal institution, key tounderstand  the historical development of Law.
Fernando de Trazegnies Granda
doaj  

Quantitative Partitioning of Photoautotrophic and Photoheterotrophic Contributions During Mixotrophic Growth of Scenedesmus obliquus

open access: yesBiotechnology and Bioengineering, EarlyView.
Carbon and oxygen fluxes during photoautotrophic, photoheterotrophic and mixotrophic growth of Scenedesmus obliquus. ABSTRACT Mixotrophic growth of microalgae involves the simultaneous assimilation of inorganic and organic carbon sources, but the quantitative contributions of photoautotrophic and photoheterotrophic metabolisms remain poorly resolved ...
Solène Jahan   +7 more
wiley   +1 more source

Purification of Disassembled Capsid Protein by Hydroxyapatite Chromatography Enhances Virus‐Like Particle Recovery

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Virus‐like particles (VLPs) are a promising modality with extensive applications in prophylactic and therapeutic vaccine design. Human Papillomavirus (HPV) vaccines are one such example where VLP vaccine applications have led to the successful reduction in HPV‐associated diseases, such as cervical cancer.
Nicholas Samuelson   +5 more
wiley   +1 more source

Reducing Cooling Costs for Sustainable Food Biomanufacturing With Thermotolerant Cupriavidus necator H16 Mutant

open access: yesBiotechnology and Bioengineering, EarlyView.
With a thermotolerant C. necator mutant the SCP production costs can be decreased by $0.98/kg. ABSTRACT Autotrophic CO2 conversion to Single Cell Protein (SCP) using H2 and O2 is gaining commercial traction for food and feed production. Cupriavidus necator H16 is a key chassis organism for this “knallgas” fermentation, but industrial operation is ...
Lars Puiman   +2 more
wiley   +1 more source

A Hybrid Mechanistic Model Capturing Lactate Run‐Away and Back‐Metabolism in Mammalian Cell Culture

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Mechanistic modeling is important in biopharmaceutical manufacturing by enabling in‐silico experimentation. However, developing a robust mechanistic model for mammalian cell culture remains challenging due to the complexity of the underlying bioprocesses.
Li Qin   +4 more
wiley   +1 more source

A Modular Micro‐Chemostat System for High‐Throughput Continuous Cultivations

open access: yesBiotechnology and Bioengineering, EarlyView.
This study presents and demonstrates a modular 12‐channel micro‐chemostat, designed to be used by Genesis, a Robot Scientist developed to automate scientific research in yeast systems biology. The bioreactor performance fulfilled the predefined requirements, and the empirical results from the biological experiments were consistent with the literature ...
Erik Y. Bjurström   +7 more
wiley   +1 more source

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