Results 221 to 230 of about 808,274 (355)

Protein Diffusion in Electroporation‐Based Biopsy: Quantifying Protein Transport From Human Skin for Skin Liquid Sampling With Electroporation

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Electroporation‐based biopsy (e‐biopsy) enables minimally invasive extraction of tissue proteins without excision; however, the effective diffusion from tissue into the sampling medium, a key parameter required for this procedure, has not been quantified in human tissues. We coupled time‐resolved aqueous sampling with a one‐dimensional Fickian
Amir Duenyas   +6 more
wiley   +1 more source

Addressing Small Data Challenges in Biopharmaceutical Development and Manufacturing: A Mini Review of Multi‐Fidelity Techniques

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT The growing demand for biopharmaceutical products reflects their effectiveness in medical treatments. However, developing new biopharmaceuticals remains a major bottleneck, often taking up to a decade before market approval. Machine learning (ML) models have the potential to accelerate this process, but their success depends on access to large
Mohammad Golzarijalal   +2 more
wiley   +1 more source

Asymmetric Dialysis: Truly Unified and Simultaneous Single‐Pass Concentration and Buffer Exchange

open access: yesBiotechnology and Bioengineering, EarlyView.
Asymmetric dialysis, a novel one‐step continuous process combining ultrafiltration and diafiltration, achieves high product concentrations (up to 200 g/L) with low pressures and reduces buffer consumption by 75% compared to conventional methods. This sustainable, low‐cost technology demonstrates significant potential for integration into continuous ...
Ujwal Patil   +3 more
wiley   +1 more source

One‐Pot Synthesis of a Small Synthetic Ligand for Antibody Purification

open access: yesBiotechnology and Bioengineering, EarlyView.
One‐pot liquid‐phase synthesis of the synthetic ligand B1Al2A2 enables controllable ligand density and efficient capture of IgG and IgY with high recovery and purity, streamlining small‐ligand affinity purification workflows. ABSTRACT The development of synthetic affinity ligands offers a cost‐effective alternative to traditional biological ligands ...
Carolina Mota Natal   +8 more
wiley   +1 more source

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