Results 41 to 50 of about 233,223 (318)

Correlation of diuretic therapy toward clinicaloutcomeof patients suffering from chronic kidney disease hospitalized in RSUP DR. M. Djamil Padang [PDF]

Pharmaciana, 2018
Kidney is one of the most important organs of the human body. The goal of diuretic therapy is to reduce edema in patients with impaired renal function. The therapy of diuretic is very important, because the therapy is effective to control of the volume ...
Fathnur Sani K, Armenia, Aina Fatkhil Haque   +2 more
doaj   +1 more source

A Framework to Ensure Patient Partners Have Equal and Contributing Voices Throughout the Research Program Evaluation Process

Canadian Journal of Kidney Health and Disease, 2020
Purpose of program: Traditionally, peer review was a closed process conducted only by individuals working in the research field. To establish a more integrated and patient-centered approach, one of Canada’s largest kidney research networks (Can-SOLVE CKD)
David R. Hillier, Mila Tang, William Clark, Cynthia MacDonald, Carol Connolly, Chantel Large, Malcolm King, Joel Singer, Adeera Levin, Braden Manns, Ana Konvalinka, James Scholey, Norman D. Rosenblum   +12 more
doaj   +1 more source

Salvianolic Acid C Inhibits the Epithelial-Mesenchymal Transition and Ameliorates Renal Tubulointerstitial Fibrosis

Frontiers in Bioscience-Landmark, 2023
Background: Salvianolic acid C (SAC) is a natural compound derived from Salvia miltiorrhiza that can protect against renal diseases. The aims of this work were to explore the effect of SAC on kidney tubulointerstitial fibrosis and study the associated ...
Ming Wu, Junyan Lin, Di Huang, Chaoyang Ye, Dongping Chen   +4 more
doaj   +1 more source

CKD-induced mitochondrial damage.

, 2018
(A) Relative expression of CytB as a marker for total mitochondrial content, relative to 18S. (B) Citrate synthase activity as an indicator for intact mitochondrial content.
Lena Cohen (4012094), Ann Saada (341104), Gad Keren (376640), Michal Entin-Meer (618054), Einat Bigelman (5367932), Zach Rozenbaum (5367935), Ran Levy (196173), Genya Aharon-Hananel (5367929)   +7 more
core   +1 more source

The systemic nature of CKD [PDF]

Nature Reviews Nephrology, 2017
The accurate definition and staging of chronic kidney disease (CKD) is one of the major achievements of modern nephrology. Intensive research is now being undertaken to unravel the risk factors and pathophysiologic underpinnings of this disease. In particular, the relationships between the kidney and other organs have been comprehensively investigated ...
Zoccali, C., Vanholder, R., Massy, Z. A., Ortiz, A., Sarafidis, P., Dekker, F. W., Fliser, D., Fouque, Denis, Heine, G. H., Jager, K. J., Kanbay, M., Mallamaci, F., Parati, G., Rossignol, P., Wiecek, A., London, G.   +15 more
openaire   +3 more sources

Identification of driver genes in renal stress condition using network clustering approach [PDF]

Network Biology, 2021
Chronic kidney disease (CKD) is a non-contagious, ageing-related and covert disease. It is a (chronic) disease of the kidneys leading to renal failure, huge public health problem worldwide and common comorbidity with type 2 diabetes mellitus (T2DM).
Mohd Murshad Ahmed, Safia Tazyeen, Rafat Ali, et al.   +2 more
doaj  

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Mechanisms of Anemia in CKD [PDF]

Journal of the American Society of Nephrology, 2012
Anemia is a common feature of CKD associated with poor outcomes. The current management of patients with anemia in CKD is controversial, with recent clinical trials demonstrating increased morbidity and mortality related to erythropoiesis stimulating agents. Here, we examine recent insights into the molecular mechanisms underlying anemia of CKD.
Jodie L, Babitt, Herbert Y, Lin
openaire   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source