Results 101 to 110 of about 1,390,749 (248)

Análisis sobre el sistema de valor de la producción sojera en la Provincia del Chaco

Revista de la Facultad de Ciencias Económicas, 2014
El enfoque de clúster refiere a una agrupación de organizaciones productivas que poseen caracteres comunes y ejercen de hecho ciertas acciones conjuntas.
Carlos Harold Gabriel Lucas
doaj   +1 more source

Segmentación de los cicloturistas de montaña en las islas baleares a través de las motivaciones de visita: un análisis clúster [PDF]

, 2017
El objetivo principal de este trabajo fue explorar el perfil del cicloturista de montaña en las islas Baleares a través de un análisis de sus motivaciones de visita.
Alemany-Hormaeche, Margarita, García-Sastre, María Antonia, Rejón-Guardia, Francisco, Rondán Cataluña, Francisco Javier (Coordinador)   +3 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Aproximación a la evaluación de un programa de financiamiento para las PyMEs bonaerenses [PDF]

, 2017
El objetivo de este trabajo es caracterizar los beneficiarios del programa de financiamiento Fuerza Productiva, otorgados en el período enero 2010 a mayo 2015 a PyMEs de la Provincia de Buenos Aires.
Corzo, Lilia José, Vigier, Hernán Pedro   +1 more
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Innovative profile of colombian manufacturing industries. Case of metal mechanics sector in barranquilla [PDF]

, 2014
This article shows the results of the study “Patterns of technological innovation in Colombian manufacturing. The case of Metal Mechanics Sector in Barranquilla.” The article begins with a detailed review of the international literature to define the ...
Amar Sepúlveda, Paola Andrea, Ovallos Gazabón, David Alfredo   +1 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Aplicación del método Scoring para la clasificación integral de clientes

Ingeniare: Revista Chilena de Ingeniería
Existen entidades que brindan servicios in situ, donde el intercambio de valor ocurre en las instalaciones del cliente, involucrando para ello un número mayor de recursos. En el trabajo se presentan dos entidades, una oferta sistemas de seguridad “llave
Rosario C Garza Ríos, Caridad N. González Sánchez, Ernesto L. Rodríguez González   +2 more
doaj  

Identification of the characteristics incident to the detection of non-technical losses for two Colombian energy companies

Revista Facultad de Ingeniería Universidad de Antioquia, 2017
El estudio de las pérdidas no técnicas que afectan a las empresas comercializadoras de energía ha orientado la mirada de los investigadores hacia diferentes técnicas y herramientas que les permitan detectar y ...
Carmen Cecilia Sánchez-Zuleta, Juan Pablo Fernández-Gutiérrez, Carlos César Piedrahita-Escobar   +2 more
doaj