Results 101 to 110 of about 1,370,885 (248)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Análisis sobre el sistema de valor de la producción sojera en la Provincia del Chaco

open access: yesRevista de la Facultad de Ciencias Económicas, 2014
El enfoque de clúster refiere a una agrupación de organizaciones productivas que poseen caracteres comunes y ejercen de hecho ciertas acciones conjuntas.
Carlos Harold Gabriel Lucas
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

L'esquema universal de clústers de 2-seccions d'una família de superfícies [PDF]

open access: yes, 2013
Generalitzem el concepte de clúster de punts d'una superfície a clúster de seccions d'una família de superfícies per passar al cas relatiu, és a dir, a clústers de B-punts d'una B-superfície.
Brustenga i Moncusí, Pau   +2 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Prospectiva del sector de calzado de cuero en Colombia, caso Calzado Yullyan [PDF]

open access: yes, 2016
Este trabajo busca aplicar los conocimientos adquiridos para identificar los problemas que se presentan en la empresa “Calzado Yullyan” y obtener posibles soluciones para lograr un mejor desempeño de la organización en el sector.
Alarcón López, Laura Victoria   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Virtualització dels serveis d'una empresa [PDF]

open access: yes, 2009
La virtualització és una tecnologia que permet l'abstracció del programari respecte dels recursos del maquinari, tant d'aplicacions com del sistema operatiu. Aquesta tecnologia està constantment en evolució, i el que fa pocs anys era un entorn de treball
Pascual Duran, Roger   +4 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Aplicación del método Scoring para la clasificación integral de clientes

open access: yesIngeniare: Revista Chilena de Ingeniería
Existen entidades que brindan servicios in situ, donde el intercambio de valor ocurre en las instalaciones del cliente, involucrando para ello un número mayor de recursos. En el trabajo se presentan dos entidades, una oferta sistemas de seguridad “llave
Rosario C Garza Ríos   +2 more
doaj  

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