Results 101 to 110 of about 1,987,455 (278)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Optimización de la Calidad de Mallas de Tetraedros en Paralelo [PDF]

open access: yes, 2013
Uno de los métodos más efectivos para la generación de mallas de calidad a partir de descripciones geométricas se basa en modificaciones locales que mejoran una métrica dada.
D'amato, Juan Pablo   +2 more
core   +1 more source

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

open access: yesScience, 2018
Phase separation and gene control Many components of eukaryotic transcription machinery—such as transcription factors and cofactors including BRD4, subunits of the Mediator complex, and RNA polymerase II—contain intrinsically disordered low-complexity ...
W. Cho   +6 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

¿El comercio lleva a la convergencia? Un análisis del efecto del TLCAN sobre la convergencia local en México

open access: yesEl Trimestre Económico, 2017
Antecedentes: La economía regional y el crecimiento económico se enfocan en la pregunta de si el comercio conlleva a una mayor concentración de la actividad económica.
Alberto Díaz Dapena   +3 more
doaj  

Conformación de clúster de turismo como prueba piloto en el municipio de Nahuizalco [PDF]

open access: yes, 2011
La conformación de un clúster turístico tiene como finalidad visible el agrupar un determinado sector de empresas que desarrollen un mercado turístico.
Cerna Aguiñada, Juan Carlos   +3 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Comparative Analysis of the Impact of Cultural and Creative Industries on GDP and Employment: A Case Study of Germany and Spain

open access: yesRevista de Economía Institucional
Este estudio presenta un análisis comparativo de las industrias culturales y creativas en España y Alemania, examinándolas en términos de conocimiento, innovación y propiedad intelectual, así como las implicaciones de sus clústeres para el crecimiento ...
Flor Marleny Gómez Reyes   +3 more
doaj   +1 more source

Clasificación de texturas naturales mediante técnicas de visión por computador en imágenes aéreas [PDF]

open access: yes, 2009
El sistema implementado consiste en una aplicación que realiza una clasificación automática de texturas en imágenes digitales a partir de un entrenamiento previo no supervisado.
Fernández Albillos, Elena   +2 more
core  

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