Results 111 to 120 of about 1,987,455 (278)

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Desafíos para América Latina en materia de capital humano y plataformas tecnológicas para implementar una política de clústeres: Costa Rica como caso de estudio.

open access: yesThe Anáhuac Journal, 2019
Las políticas de desarrollo de clústeres han llegado a fomentar la cooperación entre empresas y mejorar la competitividad regional en general. En la mayoría de los países latinoamericanos no existe una política pública en la materia como tal, por lo ...
Silvia Paola Leitón Elizondo   +1 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Estimación de pautas de asociación y patrones de distribución de edificaciones aisladas en espacios rurales mediante SIG y técnicas basadas en procesos puntuales. [PDF]

open access: yes, 2015
En este trabajo se propone un método basado en las técnicas de estadística espacial y SIG para identificar la existencia de patrones geográficos de distribución y asociación de la vivienda rural.
Galacho-Jimenez, Federico Benjamin
core  

Difusión de conocimientos e innovación en el clúster electrónico de Córdoba : análisis de las firmas miembro de una asociación empresarial [PDF]

open access: yes, 2015
La teoría de Sistemas Nacionales de Innovación (SNI) considera que las empresas no innovan de manera aislada sino en interacción con otras firmas y con la infraestructura de conocimientos; a través del ARS es posible contrastar este postulado.
Bressan, Cecilia, Matta, Andrés
core   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Cultura y consumo de energía en el sector residencial de Montevideo, Uruguay [PDF]

open access: yes, 2017
La ponencia presenta los resultados del abordaje cualitativo para el estudio del consumo de energía exosomática en hogares de Montevideo, capital del Uruguay.
Taks, Javier
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

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