Results 131 to 140 of about 1,987,455 (278)

[Prescription appropriateness in elderly patients with polypharmacy in primary care: Cluster-randomized controlled trial PHARM-PC]. [PDF]

Aten Primaria, 2021
Martínez-Sotelo J, Pinteño-Blanco M, García-Ramos R, Cadavid-Torres MI.   +3 more
europepmc   +1 more source

Planeación y despliegue de la red de sensores inalámbricos requerida para la medición inteligente de energía eléctrica usando restricciones de capacidad y cobertura [PDF]

, 2017
The electrical energy measurement (EEM), seeks to provide quality services without neglecting the reliability of the system. Therefore, a quality service must be closely linked to the wireless communication technologies, to technify the EEM, not only ...
Campaña Molina, Miguel Ángel
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Comportamiento segmentado del mercado inmobiliario y definición de patrones. Comportamiento segmentado del mercado inmobiliario y definición de patrones territoriales. Aplicación a la valoración de áreas periurbanas [PDF]

, 2013
La valoración de carácter masivo implica la modelización de un mercado que, en la mayor parte de los casos, se compone de un producto heterogéneo y con problemas de transparencia en el conocimiento de sus precios, así como de sus características ...
García Erviti, Federico, Ramírez Pacheco, Gema María   +1 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

[The new complexity: new dynamics in clusters and districts] [PDF]

, 2011
Recently, service clusters have been identified, such as in the case of the logistics and transportation cluster in the Basque Country (e.g. transportation of people and ware, intelligent transport services, etc.) or that of port activities (warehousing ...
Parrilli, M Davide
core  

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

The Lancet, 2020
J. Chan, Shuofeng Yuan, K. Kok, K. To, Hin Chu, Jin Yang, F. Xing, Jieling Liu, C. Yip, R. W. Poon, H. Tsoi, S. Lo, Kwok-Hung Chan, V. Poon, W. Chan, J. D. Ip, Jian-Piao Cai, V. Cheng, Honglin Chen, Christopher K. M. Hui, K. Yuen   +20 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source