Results 141 to 150 of about 1,987,455 (278)

Interfaz web para mostrar los genes según las relaciones que mantienen sus expresiones [PDF]

open access: yes, 2011
La investigació entre les relacions dels nivells d'expressió dels gens aporta molta informació sobre els processos biològics i patològics. Mitjançant la tècnica de les microarrays es possibilita la investigació de les relacions d'expressió de milers de ...
Gonzàlez i Sabaté, Jordi   +3 more
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

La evolución de la construcción discursiva de las trabajadoras domésticas en Chile:Una combinación de análisis crítico del discurso y lingüística de corpus [PDF]

open access: yes, 2014
Este artículo examina la construcción discursiva de las trabajadoras domésticas en Chile y busca revelar cómo estos actores sociales son representados lingüísticamente a lo largo del tiempo.
Perez, Carolina
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

una reflexión sobre la formación de los futuros profesionales del sector [PDF]

open access: yes, 2013
Ante los cambios experimentados en los estudios universitarios de turismo con la implantación del sistema europeo de educación superior, los autores se plantean un análisis de las principales áreas de conocimiento que se integran en los mismos. Para ello
Díaz Fernández, María del Carmen   +2 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Corporate innovation: a view from competitiveness, local development and productive transformation for the internationalization of Colombia [PDF]

open access: yes, 2013
Este artículo analiza la innovación en las pequeñas y medianas empresas importadoras y exportadoras de Bogotá desde el desarrollo local, la competitividad y la transformación productiva.
Cardona Acevedo, Marleny   +2 more
core  

Home - About - Disclaimer - Privacy