Results 41 to 50 of about 607 (188)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Estructura topológica del mercado bursátil de chile, período 2009-2013
Multidisciplinary Business Review, 2015 Este trabajo estudia cómo representar gráficamente un mercado bursátil. Con las series históricas de los precios semanales de las acciones negociadas en la Bolsa de Comercio de Santiago que registran una presencia bursátil anual mayor o igual a 80%, se ...
Edinson Edgardo Cornejo Saavedra +1 more
doaj
Los clústeres y la gerencia del conocimiento (GC). Cooperar y competir
Educar, 2016 El objetivo del trabajo que presentamos fue mostrar como los clústeres y las comunidades de prácticas (CoP) generan conocimiento, ventajas competitivas y crean valor al desarrollar los activos intangibles de las empresas. Se analizó un estado del arte de
Mónica Regina de Arteche
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Clústeres regionales como estrategia para superar desventajas competitivas
Revista de Investigación, Desarrollo e Innovación, 2020 El artículo tiene el objetivo de identificar cuáles son las ventajas de los clúster regionales para incentivar la competitividad de las empresas. Metodológicamente, se aborda un enfoque cualitativo a través de un ejercicio bibliométrico, que permitió la:
Diana Lorena Pineda-Ospina +2 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Ciencia y Poder Aéreo, 2018 Este artículo ofrece un panorama de los clústeres aeroespaciales a nivel mundial, tomando como referencia los más representativos de Europa, Canadá, Estados Unidos y Latinoamérica.
Wilson Estiven López Martínez +1 more
doaj +1 more source