Results 91 to 100 of about 190,921 (341)

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Blood MMP-9 measured at 2 years after lung transplantation as a prognostic biomarker of chronic lung allograft dysfunction

Respiratory Research
Background Long-term outcomes of lung transplantation (LTx) remain hampered by chronic lung allograft dysfunction (CLAD). Matrix metalloproteinase 9 (MMP-9) is a secretory endopeptidase identified as a key mediator in fibrosis processes associated with ...
Adrien Tissot, Eugénie Durand, Thomas Goronflot, Benjamin Coiffard, Benjamin Renaud-Picard, Antoine Roux, Xavier Demant, Jean-François Mornex, Loïc Falque, Mathilde Salpin, Jérôme Le Pavec, Thomas Villeneuve, Véronique Boussaud, Christiane Knoop, Antoine Magnan, David Lair, Laureline Berthelot, Richard Danger, Sophie Brouard, the COLT consortium   +19 more
doaj   +1 more source

Molecular Assessment (RNA-sequencing) of CLAD in Lung Transplant Biopsies: A Pilot Study

, 2021
Francesca Lunardi, Stefania Edith Vuljan, Federica Pezzuto, Francesco Fortarezza, Daniela Isabel Abbrescia, Giovanni Maria Comacchio, Pia Ferrigno, M. Loy, Chiara Giraudo, Anna Sara Fraia, Marco Schiavon, Fausto Braccioni, Emanuele Cozzi, Federico Rea, Francesca Schena, Fiorella Calabrese   +15 more
openalex   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Effect of Pulse Current on Interface Microstructure and Bonding Properties of TA1/304 Double-Layer Clad plates

Chinese Journal of Mechanical Engineering
It is difficult to effectively improve the low bonding strength of TA1/304 clad plates. This study proposes a new process for applying pulse current (1500 A, 500 Hz, 50% duty cycle) to TA1/304 clad plates during the rolling process, which changes the ...
Xiongwei Guo, Zhongkai Ren, Pengjie Zhang, Chao Zhang, Shuyong Jiang, Qi Zhang, Tao Wang, Qingxue Huang   +7 more
doaj   +1 more source

Chemical Upcycling of Polyphenylene Sulfide at Room Temperature

Advanced Science, EarlyView.
Poly(phenylene sulfide) (PPS) is a semi‐crystalline super engineering plastic with exceptional properties. An iron‐photocatalyzed strategy is reported for chemical upcycling of PPS plastics at room temperature using 1,2‐dichloroethane. The method demonstrates remarkable efficiency across diverse PPS resins and post‐consumer composites, even within ...
Boning Gu, Chengliang Li, Xuefeng Jiang
wiley   +1 more source

Multiphysics Simulation of Laser Cladding Process to Study the Effect of Process Parameters on Clad Geometry

, 2016
The present work reports two-dimensional simulation of laser cladding process to understand the influence of process parameters on clad geometry formation for better process optimization.
R. Parekh, R. Buddu, R. I. Patel
semanticscholar   +1 more source

A Microfiber‐Reinforced Janus Hydrogel E‐Skin With Recyclable Feature for Multimodal Sensing and Gender‐Specific Physiological Monitoring

Advanced Science, EarlyView.
Hydrogel‐based wearable electronics hold great promise for physiological monitoring in privacy‐sensitive regions. In this study, a polyurethane (PU) microfiber‐reinforced gelatin hydrogel e‐skin is developed, boasting multiple advantages such as ultra‐thinness, high toughness, and long‐term skin conformability.
Yarong Ding, Yufeng Li, Shaozhe Tan, Jiachun Sun, Xu Yang, Xuesi Zhang, Zhenhua Lin, Zhenyu Li, Yue Hao, Yannan Liu, Yingchun Li, Jingjing Chang   +11 more
wiley   +1 more source

Survival of patients with advanced chronic lung allograft dysfunction and the role of redo transplantation

JHLT Open
Background: Lung transplantation (LTx) is a treatment option for end-stage lung disease. Chronic lung allograft dysfunction (CLAD) poses challenges to long-term survival.
Zsofia Kovacs, Jens Gottlieb, Susanne Simon, Alberto Benazzo, Peter Jaksch   +4 more
doaj   +1 more source

Non‐Volatile Phase Modulation with Ultralow Energy Consumption Enabled by 2D Ferroelectric/TMD Heterostructures

Advanced Science, EarlyView.
We demonstrate a hybrid WS2/CuInP2S6/graphene heterostructure integrated on a silicon nitride microring resonator for non‐volatile optical phase modulation with ultra‐low energy consumption and low insertion loss. While CIPS alone does not provide efficient optical index modulation, the engineered proposed device structure converts ferroelctric domain ...
Lalit Singh, Shi Guo, Yuhui Yang, Sholehin Juperi, Rui Yu, Xiangxin Gong, Jeremy Leong, Sung‐Gyu Lee, Qingyun Wu, Lay Kee Ang, Sang Hoon Chae   +10 more
wiley   +1 more source