Results 31 to 40 of about 451,364 (309)

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Multivariate Frequency-Severity Regression Models in Insurance

Risks, 2016
In insurance and related industries including healthcare, it is common to have several outcome measures that the analyst wishes to understand using explanatory variables. For example, in automobile insurance, an accident may result in payments for damage
Edward W. Frees, Gee Lee, Lu Yang
doaj   +1 more source

Clinical Outcomes of Patients Within the Rheumatoid Arthritis Care Pathway Cohort at a Tertiary Care Integrated Delivery Network: A Comparison to Usual Care

Arthritis Care &Research, EarlyView.
Objective We aimed to compare clinical outcomes between patients in the Allegheny Health Network rheumatoid arthritis (RA) care pathway and patients receiving usual care. Methods The care pathway initiative implements guideline‐based best practice alongside multidisciplinary team‐based care.
Tarun Sharma, Tyson S. Barrett, Teigan Dwyer, Nancy Campbell, Jessica Heintzinger, Ellen Kraemer, Adam Dore, Susan Manzi   +7 more
wiley   +1 more source

Claim Watching and Individual Claims Reserving Using Classification and Regression Trees

Risks, 2019
We present an approach to individual claims reserving and claim watching in general insurance based on classification and regression trees (CART). We propose a compound model consisting of a frequency section, for the prediction of events concerning ...
Massimo De Felice, Franco Moriconi
doaj   +1 more source

Frequency and Severity Dependence in the Collective Risk Model: An Approach Based on Sarmanov Distribution

Mathematics, 2020
In actuarial mathematics, the claims of an insurance portfolio are often modeled using the collective risk model, which consists of a random number of claims of independent, identically distributed (i.i.d.) random variables (r.v.s) that represent cost ...
Catalina Bolancé, Raluca Vernic
doaj   +1 more source

The Comparison of the Theory of "the Difference between Existential Truths" in Peripatetic Philosophy with the Theory of "the Unity of the Truth of Existence and the Differences of its Levels" in the Transcendental Wisdom [PDF]

حکمت صدرایی, 2019
Mulla Sadra has claimed in some of his writings that there is no difference between the unity of the existence and the difference of it in the transcendentalist wisdom, with the theory of difference of existential truths in the peripatetic philosophy ...
Alireza Farsinezhad, Omid Arjomand
doaj   +1 more source

Estimation of parametric and nonparametric models for univariate claim severity distributions : an approach using R [PDF]

, 2011
This paper presents an analysis of motor vehicle insurance claims relating to vehicle damage and to associated medical expenses. We use univariate severity distributions estimated with parametric and non-parametric methods.
Bolancé, Catalina, Guillén, Montserrat, Pitt, David, Xarxa de Referència en Economia Aplicada (XREAP)   +3 more
core   +1 more source

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

Arthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer, Rui Xiao, Andrew Grossman, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +5 more
wiley   +1 more source

Ruin Probability Functions and Severity of Ruin as a Statistical Decision Problem

Risks, 2019
It is known that the classical ruin function under exponential claim-size distribution depends on two parameters, which are referred to as the mean claim size and the relative security loading. These parameters are assumed to be unknown and random, thus,
Emilio Gómez-Déniz, José María Sarabia, Enrique Calderín-Ojeda   +2 more
doaj   +1 more source

Classification of road traffic injury collision characteristics using text mining analysis: Implications for road injury prevention.

PLoS ONE, 2021
Road traffic injuries are a leading cause of morbidity and mortality globally. Understanding circumstances leading to road traffic injury is crucial to improve road safety, and implement countermeasures to reduce the incidence and severity of road trauma.
Melita J Giummarra, Ben Beck, Belinda J Gabbe   +2 more
doaj   +1 more source