Results 161 to 170 of about 3,785 (242)

Targeting KRAS for cancer therapy

open access: yesBritish Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia   +4 more
wiley   +1 more source

A novel robotic-assisted lung lobectomy simulation model. [PDF]

open access: yesJTCVS Open
Chang CC   +10 more
europepmc   +1 more source

The Serotonergic and Cholinergic Signaling Pathways Drive Gastric Precancerous Lesions and Its Potential Mechanism

open access: yesCancer Science, EarlyView.
Vagal cholinergic neurons promote gastric 5‐HT secretion, which drives gastric precancerous lesions through 5‐HTR1D and TRPV4, highlighting these as candidate targets for early intervention. ABSTRACT Gastric cancer (GC) is a leading lethal malignancy globally. Gastric precancerous lesion (GPL) represents a critical step in GC, but its neural regulatory
Shengli Gao   +8 more
wiley   +1 more source

Targeting a Novel AREG+ Dendritic Cell Alleviates Renal Fibrosis Induced by Ischemia–Reperfusion Injury

open access: yesCell Proliferation, EarlyView.
Renal IRI induces tubular EMT and fibrosis. CD11c+AREG+ DCs mediate the process via AREG‐EGFR axis, serving as promising therapeutic targets. ABSTRACT Renal ischemia–reperfusion injury (RIRI) is a major cause of acute tubular damage and a key driver of maladaptive repair and fibrosis.
Xin Luo   +14 more
wiley   +1 more source

Ultracision versus clamp-and-tie thyroidectomy: a clinical trial

open access: yes, 2009
Papavramidis, Theodosios   +6 more
openaire   +1 more source

Development of a Framework for Modelling Adhesive and Bulk Fracture in Ice: Application to Electroexpulsive Ice Protection Systems

open access: yesFatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT This study proposes a modelling framework for ice adhesive and bulk fracture. In this framework, adhesive and bulk fracture mechanisms are treated as distinct phenomena. Adhesive fracture is modelled using the well‐established cohesive zone model, which is widely used in the analysis of composite material delamination.
Pau Riera i Portillo   +3 more
wiley   +1 more source

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