Results 201 to 210 of about 37,051 (254)

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

Advanced Science, EarlyView.
The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang, Benjamin K. Law, Niles Huang, Katharine Goodwin, Celeste M. Nelson, Michelle M. Chan   +5 more
wiley   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

To clamp or not to clamp? No turning back now

BJU International, 2023
robot
Riccardo Bertolo, Alessandro Veccia, Alessandro Antonelli   +2 more
openaire   +2 more sources

Clamp loaders and sliding clamps

Current Opinion in Structural Biology, 2002
A coherent view of the structure and function of DNA polymerase processivity factors (sliding clamps and clamp loaders) is emerging from recent structural studies. Crystal structures of sliding clamps from the T4 and RB69 bacteriophages, and from an archaebacterium expand the gallery of ring-shaped processivity factors and clarify how the clamp ...
David, Jeruzalmi, Mike, O'Donnell, John, Kuriyan   +2 more
openaire   +2 more sources

Delayed Versus Immediate Cord Clamping in Preterm Infants

New England Journal of Medicine, 2017
Background: The preferred timing of umbilical-cord clamping in preterm infants is unclear. Methods: We randomly assigned fetuses from women who were expected to deliver before 30 weeks of gestation to either immediate clamping of the umbilical cord (=10 ...
Ian Wright, Neil Marlow, Walid El-Naggar
exaly   +2 more sources

Design and simulation of Clamped-Clamped and Clamped-Free resonators

Fifth Asia Symposium on Quality Electronic Design (ASQED 2013), 2013
To date, there have been interests in designing the Micro-Electro-Mechanical System (MEMS) integrated with Complementary Metal-Oxide Semiconductor (CMOS) resonator for RF integrated circuits. This work presents the design of Clamped-Clamped (CC) and Clamped-Free (CF) beam resonators.
A. Anwar Zainuddin, Jamilah Karim, A. Nurashikin Nordin, M. Soundara Pandian, K. Sheroz   +4 more
openaire   +1 more source

Finger Clamping Unit: A Clamping Device with a Large Clamping Range

International Journal of Precision Engineering and Manufacturing, 2021
Finger Clamping Unit (FCU) is a small-sized single-point clamp developed to clamp thin object of various thicknesses. It has a six-bar linkage with one compliant link, uses an electric motor as an actuator and induces toggle-lock motion by singular configuration.
Youngjae Jeon, Joohyun Oh, Jongwon Kim, TaeWon Seo   +3 more
openaire   +1 more source

To Clamp or Not To Clamp During Partial Nephrectomy

European Urology, 2015
Simply put, the benefit of partial nephrectomy (PN) in renal mass patients, compared with radical nephrectomy (RN), is preservation of renal function. This advantage is paramount in patients with imperative situations (bilateral renal tumors, solitary kidney, or impaired baseline renal function) but can also be a decided advantage in elective ...
openaire   +2 more sources