Results 161 to 170 of about 768,011 (297)

Clarity of Vision

Academic Medicine, 2016
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The moderating role of self-efficacy in influencing the level of competencies among Middle Nurse Managers: A cross-sectional study. [PDF]

J Nurs Scholarsh
Ivziku D, Curcio F, Filomeno L, Lachi A, D'Agostino F, Giannetta N, Forte D, Gori N, Gonzalez CIA, Tartaglini D.   +9 more
europepmc   +1 more source

Letter re: bet

, 1926
Letter from F. E. Clarity, vice president and general manager of the Fort Worth and Denver City Railway Company, to Amon Carter regarding a bet made on the results of the Texas governor's ...
Clarity, Frank E.
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Quality of Life Among Saudi Mothers of Children with Autism Spectrum Disorder: Associations with Caregiver Burden, Psychological Distress, Financial Experiences, and Post-Diagnosis Service Pathway Clarity. [PDF]

Healthcare (Basel)
Al Awaji NN, Aldursuni AA, Almutairi FM, Alanazi AM, Alanazi RA, Alhurayyis BA, Alwajee RA, Alghamdi A, Alabdulkarim S.   +8 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Web-Based Educational Application for Mental Health Self-Monitoring After Bariatric Surgery: Development and Content Validation Study. [PDF]

JMIR Form Res
Polaro A, Machado RM.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Coping With COVID-19's Demanding Collective Goals: Is a Normative Context in Favour of Governmental Measures Related to Social Cohesion? [PDF]

Can Rev Sociol
Pelletier-Dumas M, Lacourse É, Stolle D, Lina JM, de la Sablonnière R.   +4 more
europepmc   +1 more source