Results 231 to 240 of about 2,132,802 (281)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Design considerations for miniaturized biosensor-enabled systems for older adults: insights from participatory design. [PDF]

Front Bioeng Biotechnol
Quidato M, Suarez MT, Ebardo R.
europepmc   +1 more source

Erratum for the Research Article "Genetic history of Scythia" by T. Andreeva <i>et al</i>.

Sci Adv
europepmc   +1 more source

The role of loneliness and self-concept clarity in the relationship between problematic mobile social network usage and social anxiety among college students. [PDF]

Front Psychol
Fang H, Xu X, Yang S.
europepmc   +1 more source

Validity and Reliability of SCOPE (Structured Comprehensive Oral Problem-based Examination) using Generalizability and Decision Study. [PDF]

Pak J Med Sci
Sabqat M, Ain N, Khan RA.
europepmc   +1 more source

Development and Content Validity of a Pre-participation Evaluation Tool for Recreational Athletes Engaged in High-Intensity Sports. [PDF]

Cureus
Patil SC, S A.
europepmc   +1 more source

Bridging the stroke care gap: development and validation of CaknaStrok Education Package (CEP) for caregivers of stroke survivors in Malaysia. [PDF]

BMJ Open
Sidek NN, Kamalakannan S, Musa KI, Long Tuan Kechik TSM, Hamzah N, Abd Hamid RI, Darus D, Ibrahim KA, Seman N, Ahamad Fouzi L, Abdul Hamid F, Ismail TAT.   +11 more
europepmc   +1 more source