Results 91 to 100 of about 1,240,744 (292)

Redesigning More Resilent Sahana System For Disaster Information In Indonesia [PDF]

, 2011
This application is a disaster information system in Indonesia using Sahana platform that has many unique features of the integration Sahana disaster with some applications that have been built independently in the previous year of mudflow in Sidoarjo ...
Arna, Fariza, Idris , Winarno, Jauari , Akhmad, Robiatul , Kamelia, Wahjoe , Tjatur S   +4 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A fuzzy multi-objective class based storage location assignment

, 2011
The required storage space and the material handing cost in a warehouse hinge on the storage implementation decision. Effects of storage area reduction on order picking and storage space cost are incorporated. Moreover, merchandises which are in the same shape and can be stored beside each other easily or goods that don't cause any danger like causing ...
Maleki Vishkaei, Behzad, Rashti, Mahdi EbrahimNezhad Moghadam   +1 more
openaire   +3 more sources

Large protein organelles form a new iron sequestration system with high storage capacity

eLife, 2019
Iron storage proteins are essential for cellular iron homeostasis and redox balance. Ferritin proteins are the major storage units for bioavailable forms of iron. Some organisms lack ferritins, and it is not known how they store iron.
Tobias W Giessen, Benjamin J Orlando, Andrew A Verdegaal, Melissa G Chambers, Jules Gardener, David C Bell, Gabriel Birrane, Maofu Liao, Pamela A Silver   +8 more
doaj   +1 more source

A Quasi-Steady State Model of a Singularly Perturbed Wind Turbine with an Induction Generator and Nonlinear Frictions: A Bond Graph Approach

Journal of Engineering, 2020
The modelling in bond graph of a class of nonlinear systems with singular perturbations is presented. The class of nonlinear systems modelled by bond graphs is defined by the product of state variables and nonlinear dissipation elements.
Aaron Padilla-Garcia, Gilberto Gonzalez-Avalos, Noe Barrera-Gallegos, Gerardo Ayala-Jaimes   +3 more
doaj   +1 more source

NanoFS: a hardware-oriented file system [PDF]

, 2013
NanoFS is a novel file system for embedded systems and storage-class memories (like flash) and is specially designed to be directly implemented in hardware.
Bellido Díaz, Manuel Jesús, Guerrero Martos, David, Juan Chico, Jorge, Ostúa Arangüena, Enrique, Ruiz de Clavijo Vázquez, Paulino, Viejo Cortés, Julián   +5 more
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PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Perancangan Ulang Tata Letak Produk Dengan Metode Class Based Dan Randomized Storage (Studi Kasus di Toko Vivi) [PDF]

, 2017
Vivi store is one of the shops that sell daily necessities such as rice, cooking oil, sugar, flour, milk, soap, etc. The percentage of expenditures for material handling costs incurred on operating costs is 15,934%.
., Noverlina
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