Results 181 to 190 of about 34,763,689 (253)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

E-cigarette and cannabis use and co-use patterns and dependence trajectories among young adults in the United States. [PDF]

Addiction
Pokhrel P, Phillips KT, Phillips MM, Kawamoto CT, Herzog TA.   +4 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The structure of the native cardiac crossbridge in the rigor state. [PDF]

Sci Adv
Risi CM, Nguyen T, Belknap B, White HD, Pinto JR, Chase PB, Galkin VE.   +6 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Association Between Surgeons' Consideration of Suspected Biliary Contamination and Reported Antibiotic Duration After Pancreatoduodenectomy: An Exploratory Secondary Analysis of an International Survey. [PDF]

Antibiotics (Basel)
Hoffmann M, Farkas D, Schepp F, Neizert CA, Poch FGM, Beyer K, Pinto D.   +6 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Association of physical activity domains and television time with mental health profiles in Brazilian adolescents: a latent class analysis. [PDF]

Cad Saude Publica
Cardoso GCDA, Costa RMD, Costa BGGD, Guerra PHA, Mota J, Autran RG.   +5 more
europepmc   +1 more source

Cold-adaptive variations in the membrane lipid composition in polar species of the ciliate <i>Euplotes</i>. [PDF]

Front Microbiol
Anesi A, Alimenti C, Luporini P, Guella G, Vallesi A.   +4 more
europepmc   +1 more source

Integrated Genomic and Proteomic Analysis Reveals T-B Lymphocyte Signatures in the MYCN Driven "Immune Desert" of Specific Neuroblastoma Subtypes. [PDF]

CNS Neurosci Ther
Hu JJ, Kang WJ, Hu JT, Li YX, Song FJ, Deng M.   +5 more
europepmc   +1 more source