Results 61 to 70 of about 1,562,038 (265)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Davvero può esistere un nuovo spirito scientifico?
Im@go. A Journal of the Social Imaginary, 2019 This paper intends to start from the recent reprint of the "new scientific spirit" of the French philosopher Gaston Bachelard. The questions we ask to the text are linked to the sociology of the imaginary and to the sociology of the media. To investigate
Vincenzo Del Gaudio
doaj
Investigation of temperature variations on a Class-E inverter and proposing a compensation circuit to prevent harmful effects on biomedical implants. [PDF]
Sci Rep, 2023 Khodadoost M, Hayati M, Abbasi H.
europepmc +1 more source
A Transformer Class E Amplifier
Archives of Electrical Engineering, 2014 Abstract In a high-efficiency Class E ZVS resonant amplifier a matching and isolation transformer can replace some or even all inductive components of the amplifier thus simplifying the circuit and reducing its cost. In the paper a theoretical analysis, a design example and its experimental verification for a transformer Class E amplifier are presented.
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Tensões Mundiais, 2018 Analiso sociologicamente o pensamento internacionalista de Gramsci, interpretando como conciliou ideais inerentes ao “internacionalismo proletário” com a demanda de unificação nacional italiana. A metodologia consiste em traçar um paralelo entre biografia e “Escritos Políticos”, expondo suas primeiras investidas em prol da independência da Sardenha ...
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Molecular Cloning and Expression Profile of Class E Genes Related to Sepal Development in Nelumbo nucifera. [PDF]
Plants (Basel), 2021 Liu Z +9 more
europepmc +1 more source