Results 121 to 130 of about 36,491,622 (296)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Applications of the genetic algorithm optimisation approach in the design of high efficiency microwave class E power amplifiers [PDF]
In this thesis Genetic Algorithm Optimisation Methods (GA) is studied and for the first time used to design high efficiency microwave class E power amplifiers (PAs) and associated load patch antennas.
Lu, Qing
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Applied SciencesThis paper presents a comprehensive analysis of Class-E series-tuned radio-frequency power amplifiers (RFPAs), focusing on their design and optimization for high efficiency and performance. However, achieving optimal performance involves navigating trade-
Pallab Kr Gogoi +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Control Theory for a Class of 2D Continuous-Discrete Linear Systems
, 2004 This paper considers a general class of 2D continuous-discrete linear systems of both systems theoretic and applications interest. The focus is on the development of a comprehensive control systems theory for members of this class in a unified manner ...
Owens, D H +4 more
core +1 more source
Design methodology and characteristics of a class E autogenerator
Технологія та конструювання в електронній апаратурі, 2002 An autogenerator with an output power of 1 W and an efficiency of 86% at a frequency of 800 kHz is calculated and experimentally investigated. A specific feature of the autogenerator is its low supply voltage and weak dependence of the generation ...
V. H. Kryzhanovskyi +2 more
doaj
The ... report of the secretary of the Class of 1862 of Harvard College.
"Printed for the use of the class."Description based on: 3rd (June 1875).Mode of access ...
Harvard College (1780- ). Class of 1862.
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source