Results 91 to 100 of about 1,595,967 (267)

Entre a classe e a multidão

Revista Opinião Filosófica, 2021
O presente trabalho tem por objetivo realizar, primeiramente, uma ligeira introdução da concepção de de carne biopolítica, na medida em que se perpassa por diferentes autores, os quais serão explicitamente perseguidos com o objetivo de sinalizar os substratos através dos quais se fundamenta uma perspectiva ontológica materialista, sendo ela a expressão
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Optimization Design of Load-Independent Class-E$^{2}$ DC-DC Converter With Performance Visualization

IEEE Open Journal of Power Electronics
This paper proposes an analysis and design method for the load-independent class-E$^{2}$ DC-DC converter, which is composed of the load-independent class-E inverter and the load-independent class-E synchronous rectifier.By combining the newly derived ...
Tatsuki Osato, Xiuqin Wei, Hiroo Sekiya
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Switch-Mode and Waveform Shaping Inverter With an Intrinsically Adjustable Nonlinear Output Capacitance

IEEE Access
In this paper, the analysis and design of a class-E/Fn inverter using analytically expressions is provided for any grading coefficient m of the MOSFET body junction diode at 50% duty ratio.
Ali Lotfi, Mahmoud Shahbazi, Walid Issa, Patrick Wheeler, Hiroo Sekiya, Marian K. Kazimierczuk, Frede Blaabjerg   +6 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Investigating the Bounds of Quality Factor for Class-E Series-Tuned RF Power Amplifiers and Their Computer-Aided Optimization

Applied Sciences
This paper presents a comprehensive analysis of Class-E series-tuned radio-frequency power amplifiers (RFPAs), focusing on their design and optimization for high efficiency and performance. However, achieving optimal performance involves navigating trade-
Pallab Kr Gogoi, Ayan Sharma, Jurgen Vanhamel, Jérôme Loicq   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source