Results 51 to 60 of about 1,047 (204)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Modeling and Control of DC to High-Frequency AC Voltage Conversion for Photovoltaic Systems Under Variable Irradiation, Temperature and Load Conditions

Electrica
: This study introduces a model that adjusts the DC voltage output from PV panels through a Cuk Converter while a Class-E inverter produces a high-frequency AC voltage.
Fatih Issi, Mustafa Karhan
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A criação do Hospital Doutor Dório Silva e a configuração de vagas para enfermeiros La creación del Hospital Doutor Dório Silvia y la configuración de plazas para enfermeros The creation of Doutor Dório Silva Hospital and the configuration of positions for nurses

Escola Anna Nery, 2008
Pesquisa histórico-social com abordagem dialética cujo objeto foi a configuração de vagas para enfermeiros no Hospital Doutor Dório Silva (HDDS); traçaram-se como objetivos descrever os antecedentes históricos do movimento de criação do HDDS e analisar ...
Maria Carlota de Rezende Coelho, Maria da Luz Barbosa Gomes   +1 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Class E ZVS Resonant Inverter with CLC Filter and PLL-Based Resonant Frequency Tracking for Ultrasonic Piezoelectric Transducer

Journal of Low Power Electronics and Applications
This paper presents a Class E zero-voltage soft-switching (ZVS) resonant inverter integrated with a CLC filter and a digital resonant frequency tracking technique for driving a piezoelectric ceramic transducer (PZT) in ultrasonic cleaning applications. A
Apinan Aurasopon, Boontan Sriboonrueng, Jirapong Jittakort, Saichol Chudjuarjeen   +3 more
doaj   +1 more source

Introduction to the Inaugural Issue

Journal of Advances in Information Technology, 2010
In this inaugural issue, we present a variety of papers to cover, as much as possible, the breadth and depth of the intended scope of JAIT. We begin with a survey paper by Khan et al. on machine learning techniques for text document classification.
A.C.M. Fong
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Sistema Electrónico Inteligente para el Control de la Interconexión entre Equipamiento de Generación Distribuida y la Red Eléctrica

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2017
Resumen: Las transformaciones que están teniendo lugar en el sector eléctrico están haciendo evolucionar la red hacia un modelo más inteligente y eficiente conocido como Smart Grid.
Rafael Real-Calvo, Antonio Moreno-Munoz, Victor Pallares-Lopez, Miguel J. Gonzalez-Redondo, Isabel M. Moreno-Garcia, Emilio J. Palacios-Garcia   +5 more
doaj   +1 more source