ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Identification of multiple prognostic biomarker sets for risk stratification in SKCM. [PDF]
Malik S, Tomer R, Arora A, Raghava GPS.
europepmc +1 more source
Class 1 Indications for Coronary Revascularization Identified in Prekidney Transplant Screening
Avantika Israni +10 more
openalex +2 more sources
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Correction: Machine learning-based detection of cognitive decline using SSWTRT: classification performance and decision analysis. [PDF]
Nozaki Y +5 more
europepmc +1 more source
AllokAcad-back: backend and business rules of the class assignment system
Felipe Matheus Vitorino de Mattos Silva +1 more
openalex +2 more sources
Predation vs. Parasitism: A Case Study of Indigenous Co-Stewardship and Science Co-Production to Measure Temporal Shifts in Moose Mortality on Ancestral Lands of the Grand Portage Ojibwe. [PDF]
Garwood TJ +7 more
europepmc +1 more source
Prioritizing Pharmaceuticals for Environmental Monitoring in Greece: A Comprehensive Review of Consumption, Occurrence, and Ecological Risk. [PDF]
Chatzipanagiotou KR +4 more
europepmc +1 more source

