Results 31 to 40 of about 1,050,785 (297)

The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. [PDF]

, 2010
Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma.
Alex Berndt, Benjamin T Houseman, Christian Rommel, Daniel D Le, Fabrice Gorrec, Jeffrey P Shaw, Joseph I Pacold, Kevan M Shokat, Matthias K Schwarz, Olusegun Williams, Pascale Gaillard, Pingda Ren, Roger L Williams, Simon Miller, Thomas Rückle, Wai-Ching Hon, Yi Liu   +16 more
core   +2 more sources

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. [PDF]

, 2018
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer. Poly-chemotherapy with cytotoxic and genotoxic drugs causes substantial toxicity and more specific therapies targeting the underlying molecular lesions are highly desired ...
Donker, Lisa, Ducker, Gregory S, Jun, Jesse, Ksionda, Olga, Matlawska-Wasowska, Ksenia, Mues, Marsilius, Roose, Jeroen P, Shannon, Kevin, Shokat, Kevan M, Tenhagen, Milou, Wandler, Anica M   +10 more
core   +3 more sources

Understanding summertime peroxyacetyl nitrate (PAN) formation and its relation to aerosol pollution: insights from high-resolution measurements and modeling [PDF]

Atmospheric Chemistry and Physics
Peroxyacetyl nitrate (PAN), a key indicator of photochemical pollution, is generated similarly to ozone (O3), through reactions involving specific volatile organic compounds (VOCs) and nitrogen oxides.
B. Hu, B. Hu, B. Hu, N. Chen, N. Chen, R. Li, M. Huang, M. Huang, M. Huang, J. Chen, J. Chen, Y. Hong, Y. Hong, L. Xu, L. Xu, X. Fan, X. Fan, M. Li, M. Li, L. Tong, Q. Zheng, Y. Yang   +21 more
doaj   +1 more source

Assessing the Robustness of Pan Evaporation Models for Estimating Reference Crop Evapotranspiration during Recalibration at Local Conditions

Hydrology, 2020
A classic method for assessing the reference crop evapotranspiration (ETo) is the pan evaporation (Epan) method that uses Epan measurements and pan coefficient (kp) models, which can be functions of relative humidity (RH), wind speed (u2), and ...
Konstantinos Babakos, Dimitris Papamichail, Panagiotis Tziachris, Vassilios Pisinaras, Kleoniki Demertzi, Vassilis Aschonitis   +5 more
doaj   +1 more source

تأثیر اثر کاربرد برگی اسید سالیسیلیک بر وزن خشک، شاخص برداشت، عملکرد و اجزای عملکرد لوبیا چشم‌بلبلی (Vigna unguiculata L.) تحت تنش کم‌آبی [PDF]

تنش های محیطی در علوم زراعی, 2016
به‌منظور بررسی اثر کاربرد برگی اسید سالیسیلیک بر عملکرد و اجزای عملکرد لوبیا چشم‌بلبلی (Vigna unguiculata L.) رقم پرستو، تحت تنش کم آبی، آزمایشی در قالب طرح اسپیلت بلوک در سال زراعی 1388 در مزرعه تحقیقاتی دانشگاه زنجان انجام شد. تیمارهای آزمایشی شامل تنش
مالک اژدر افشاری, فرید شکاری, کامران افصحی, رقیه عظیم خانی   +3 more
doaj   +1 more source

The energy balance of a US Class A evaporation pan

Agricultural and Forest Meteorology, 2013
Abstract Concurrent with the trend of rising global average air temperature, there have been worldwide observations of a decline in pan evaporation over the last 30–50 years. This global phenomenon has since received much attention from the scientific community.
Lim, Wee Ho, Roderick, Michael, Hobbins, Michael T, Wong, Suan Chin, Farquhar, Graham   +4 more
openaire   +2 more sources

Class A pan coefficients (Kp) to estimate daily reference evapotranspiration (ETo) [PDF]

Revista Brasileira de Engenharia Agrícola e Ambiental, 2003
The class A pan coefficient (Kp) has been used to convert pan evaporation (ECA) to grass-reference evapotranspiration (ETo), an important component in water management of irrigated crops. There are several methods to determine Kp values, using wind speed, relative humidity and fetch length and conditions.
Sentelhas, Paulo C., Folegatti, Marcos V.   +1 more
openaire   +3 more sources

Pan-STARRS1 Discovery of Two Ultra-Luminous Supernovae at z ~ 0.9 [PDF]

, 2011
We present the discovery of two ultra-luminous supernovae (SNe) at z ~ 0.9 with the Pan-STARRS1 Medium-Deep Survey. These SNe, PS1-10ky and PS1-10awh, are amongst the most luminous SNe ever discovered, comparable to the unusual transients SN 2005ap and ...
A. M. Soderberg, A. Rest, A. Riess, Abazajian, Barbary, C. W. Stubbs, Chatzopoulos, Chevalier, Chevalier, Chevalier, Contardo, D. C. Martin, Drout, E. A. Magnier, E. Berger, Faber, Foley, Frail, Frail, G. Narayan, Gaensler, Gezari, Gänsicke, H. Flewelling, Hogg, I. Czekala, Immler, Ivezic, J. D. Neill, J. L. Tonry, J. S. Morgan, Jeffery, K. C. Chambers, K. C. Roth, K. Forster, Kasen, Katz, Kewley, Kocevski, L. Chomiuk, M. E. Huber, MacFadyen, Magnier, Malesani, Miller, Mink, Modjaz, N. E. Sanders, N. Kaiser, Nakar, Neill, Nugis, Ofek, Onaka, P. A. Price, Pastorello, Perley, Quimby, R. A. Chevalier, R. Chornock, R. J. Foley, R. J. Wainscoat, R. P. Kirshner, R.-P. Kudritzki, Rest, S. A. Rodney, S. Gezari, S. J. Smartt, Schlegel, Shklovskii, Smith, Smith, Smith, Stoll, Stubbs, Tonry, Tremonti, van der Horst, W. M. Wood-Vasey, W. S. Burgett, Woosley, York   +81 more
core   +5 more sources

Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]

, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V., Brindley, Paul J., Bulman, Christina A., Elfawal, Mostafa A., Helander, Jon, Janetka, James W., Mitreva, Makedonka, Rosa, Bruce A., Sakanari, Judy, Tyagi, Rahul, Wildman, Scott A.   +10 more
core   +3 more sources

Preparação e Caracterização de Blendas Híbridas de Poliacrilonitrila e Quitosana

Orbital: The Electronic Journal of Chemistry, 2015
In this work we report O estudo da interação de íons Fe(II) com a polianilina foi feito através da obtenção deste polímero na forma de salthe studies on polymer blend using the polymers polyacrylonitrile (PAN) and chitosan (CHI) in two compositions ...
Alessandro Cruz Seabra, Eloi Alves Silva Filho, Edumar Ramos Cabral Coelho, Flávio Vinicius Crizóstomo Kock   +3 more
doaj   +1 more source