Results 61 to 70 of about 1,054,901 (276)

A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer. [PDF]

, 2017
Lessons learnedThe combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate ...
Friedlander, Terence, Hsieh, Andrew C, Kim, Won, Lin, Amy M, Louttit, Mirela, Ryan, Charles J, Wei, Xiao X   +6 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Reference evapotranspiration estimation inside greenhouses

Scientia Agricola, 2003
Because of the large area occupied by a class A pan, alternative methods have been sought to estimate reference evapotranspiration (Eto) inside greenhouses. The objective of this work was to compare ETo estimated by different methods inside and outside a
Carolina Fernandes, José Eduardo Corá, Jairo Augusto Campos de Araújo   +2 more
doaj  

Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells

International Journal of Cell Biology, 2017
Exposure to maternal cortisol plays a crucial role in fetal organogenesis. However, fetal overexposure to cortisol has been linked to a range of short- and long-term adverse outcomes.
Katie L. Togher, Louise C. Kenny, Gerard W. O’Keeffe   +2 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Comparison of Class A pan, tank, and Piche evaporimeter

MAUSAM, 1980
The object of this paper is to study the variation of evaporation Karaj (Long. 51 deg. 00 min. E,  Lat. 35 deg. 48 min., Alt. 1321 m) by different evaporimeters and comparison, the results to find out suitable conversion factor. The results of analysis of 2 years (1975-76) data of evaporation show that the correlation Coefficient between Piche and U.S ...
openaire   +2 more sources

Evaluation of Five Methods for Estimating Class A Pan Evaporation in a Humid Climate [PDF]

HortTechnology, 2003
Evaporation pans continue to be used extensively throughout the world to measure free-surface water evaporation (E pan ) and to estimate evapotranspiration for irrigation scheduling and water management for agronomic and horticultural crops.
Suat Irmak, Dorota Z. Haman
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Crescimento vegetativo e produtividade do cafeeiro irrigado no sul do Estado de Minas Gerais Vegetative growth and yield of irrigated coffee in southern region of State of Minas Gerais - Brazil

Revista Brasileira de Engenharia Agrícola e Ambiental, 2007
O conhecimento e o manejo dos principais fatores relacionados à produção, dentre os quais a irrigação é de fundamental importância, razão por que se objetivou, com este trabalho, avaliar o efeito de diversas lâminas de irrigação no crescimento vegetativo,
Natalino M. Gomes, Luiz A. Lima, Anselmo A. de P. Custódio   +2 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source