Results 61 to 70 of about 197,603 (248)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
A New Low-Voltage, Low-Power and High-Slew Rate CMOS Unity-Gain Buffer
Iranian Journal of Electrical and Electronic Engineering, 2014 Class-AB circuits, which are able to deal with currents several orders of magnitude larger than their quiescent current, are good candidates for low-power and high slew-rate analog design.
M. Piry, M. Khanjani Moaf, P. Amiri
doaj
Power-efficient class AB CMOS buffer
Electronics Letters, 2009 A novel class AB unity gain voltage buffer is proposed. It is based on the use of quasi-floating gate (QFG) techniques in a super source follower topology. The circuit achieves dynamic current boosting with accurate control of quiescent currents and without penalty in supply voltage requirements or quiescent power consumption.
A.J. Lopez-Martin +3 more
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Association of GH/HaeIII polymorphism with growth and developmental traits of Morkaraman sheep [PDF]
Archives Animal BreedingThis study investigated the impact of GH gene polymorphism in Morkaraman ewes on placental traits and lamb development characteristics across three years (2020–2022) at Atatürk University Sheep Farm, Erzurum.
U. Dagdelen, N. Esenbuga
doaj +1 more source
CMOS low noise class AB buffer
Electronics Letters, 1999 A novel CMOS class AB buffer circuit realisation is presented. The proposed circuit retains a simple realisation and provides low power class AB operation. It is shown that the class AB circuitry does not contribute to the noise performance of the circuit. Experimental results from a 1.2 /spl mu/m chip for the buffer and filter circuits are presented.
H. Elwan, M. Ismail
openaire +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Antimicrobial Resistance and Infection Control, 2017 Background Molecular analysis of carbapenem-resistant genes in Acinetobacter baumannii, an emerging pathogen, is less commonly reported from Nepal. In this study we determined the antibiotic susceptibility profile and genetic mechanism of carbapenem ...
Prabhu Raj Joshi +5 more
doaj +1 more source