Results 101 to 110 of about 2,322,151 (276)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Characterizing Cautious Choice [PDF]

The class of maximin actions in general decision problems is characterized.Maximin actions;Decision ...
Borm, P.E.M., Fiestras-Janeiro, G., Garcia-Jurado, I., Mosquera, M.A., Voorneveld, M.   +4 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Class Actions and Beyond: Unraveling the Link Between Corporate Decision-Making and Risk Prediction in the Age of Machine Learning

FinTech
This study delves into the domain of corporate litigation risk, particularly through the prism of securities class actions, by leveraging financial datasets and trading metrics to broaden the scope of predictability for securities class-action litigation
Fei (Phoebe) Gao, Yew Kee Ho, Kevin Ow Yong   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The class actions in italy: problems and perspectives in comparative analysis
Le class actions in italia: problemi e prospettive in chiave comparata

Scientia Iuris, 2008
The Italian financial laws for 2008 introduce, in Article 2, item 445, the first organic discipline of class actions in the Italian order. The decision made by the Italian legislator is, therefore, meaningful in relation not only to the effects produced ...
Gianluca Sgueo
doaj  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

CLASS: A Framework for Strategic Thinking and Actions during Academic and Workplace Transitions

Journal of College Orientation, Transition, and Retention
The CLASS framework is a versatile tool college students can use when learning how to proactively and intentionally navigate new educational and work environments.
Adam Denney, Sarah C. Williams , Danielle Dietz, Alysha Gray   +3 more
doaj   +1 more source