Results 71 to 80 of about 209,106 (263)

Catchment transit time variability with different SAS function parameterizations for the unsaturated zone and groundwater [PDF]

Hydrology and Earth System Sciences
Preferential flow paths (e.g., macropores or subsurface pipe networks) in hydrological systems facilitate the rapid transmission of precipitation and solutes to streams, resulting in streamflow responses characterized by the release of younger water (i.e.
H. Türk, C. Stumpp, M. Hrachowitz, P. Strauss, G. Blöschl, M. Stockinger   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Large protein organelles form a new iron sequestration system with high storage capacity

eLife, 2019
Iron storage proteins are essential for cellular iron homeostasis and redox balance. Ferritin proteins are the major storage units for bioavailable forms of iron. Some organisms lack ferritins, and it is not known how they store iron.
Tobias W Giessen, Benjamin J Orlando, Andrew A Verdegaal, Melissa G Chambers, Jules Gardener, David C Bell, Gabriel Birrane, Maofu Liao, Pamela A Silver   +8 more
doaj   +1 more source

A Quasi-Steady State Model of a Singularly Perturbed Wind Turbine with an Induction Generator and Nonlinear Frictions: A Bond Graph Approach

Journal of Engineering, 2020
The modelling in bond graph of a class of nonlinear systems with singular perturbations is presented. The class of nonlinear systems modelled by bond graphs is defined by the product of state variables and nonlinear dissipation elements.
Aaron Padilla-Garcia, Gilberto Gonzalez-Avalos, Noe Barrera-Gallegos, Gerardo Ayala-Jaimes   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Correction: Layout optimization of irregular storage areas under class storage strategy based on clustering and multi-bin size packing problem.

PLoS ONE
[This corrects the article DOI: 10.1371/journal.pone.0307218.].
Wenbin Zhang, Yuejun Jin, Huarong Zhang, Yiming Wang   +3 more
doaj   +1 more source

AS/RS travel time with horizontal deployment in class-based storage areas: a new formula

Production and Manufacturing Research: An Open Access Journal
The enhancement of warehouse processes is pivotal in internal logistics activities and it is a lever of competitive advantage for companies that are operating in more turbulent business environment.
Abror Hoshimov, Anna Corinna Cagliano, Giulio Mangano, Maurizio Schenone   +3 more
doaj   +1 more source

Storage Optimization at PT XY Using Class Based Storage and FSN Analysis Methods

G-Tech: Jurnal Teknologi Terapan
This research aims to make the process of picking goods according to their type easier, so that the distance of transporting materials is shorter than the previous distance. FSN Analysis classifies goods based on the frequency of demand, and Class Based Storage groups goods based on their category (FSN) and places them in strategic locations in the ...
Septian Aditya, Said Salim Dahda
openaire   +1 more source