Results 41 to 50 of about 1,263,097 (263)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Sequences of Bubbles and Holes: New Phases of Kaluza-Klein Black Holes

open access: yes, 2004
We construct and analyze a large class of exact five- and six-dimensional regular and static solutions of the vacuum Einstein equations. These solutions describe sequences of Kaluza-Klein bubbles and black holes, placed alternately so that the black ...
B. Kol   +37 more
core   +3 more sources

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

open access: yesFEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii   +8 more
wiley   +1 more source

A Transfer Matrix study of the staggered BCSOS model

open access: yes, 1996
The phase diagram of the staggered six vertex, or body centered solid on solid model, is investigated by transfer matrix and finite size scaling techniques. The phase diagram contains a critical region, bounded by a Kosterlitz-Thouless line, and a second
Carlon, Enrico   +2 more
core   +2 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

UML class diagram object-oriented metrics: algorithms of calculation

open access: yesITM Web of Conferences, 2018
The paper proposes algorithms of the object oriented UML class diagram metrics calculation. Metrics include Average CBO, Average DIT, Average NOC, Average DAC, Average NLM, Average NOM, DAC2, SIZE2, and DSC.
Deryugina Olga
doaj   +1 more source

PENGGUNAAN AUGMENTED REALITY UNTUK MEMFASILITASI PERUBAHAN REPRESENTASI KONSEPTUAL SISWA TENTANG SISTEM ENDOKRIN DAN PENGUASAAN KONSEP

open access: yesJurnal Pendidikan Biologi, 2021
Abstrak. Penelitian ini bertujuan untuk mengidentifikasi penggunaan Augmented Reality (AR) dalam memfasilitasi perubahan representasi konseptual siswa tentang sistem endokrin dan penguasaan konsep.
Nisrina Dwi Fajriani   +2 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Phase Diagram of Traffic States in the Presence of Inhomogeneities

open access: yes, 1999
We present a phase diagram of the different kinds of congested traffic that are triggered by disturbances when passing ramps or other spatial inhomogeneities of a freeway.
Helbing, Dirk   +2 more
core   +2 more sources

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