Results 111 to 120 of about 1,926,214 (266)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Unsupervised two-class & multi-class support vector machines for abnormal traffic characterization. [PDF]

open access: yes, 2009
Although measurement-based real-time traffic classification has received considerable research attention, the timing constraints imposed by the high accuracy requirements and the learning phase of the algorithms employed still remain a challenge. In this
Kim, Hyun-chul   +7 more
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

La sconfitta del linguaggio. L'impossibilità di narrare il Male: W ou le souvenir d'enfance

open access: yesIm@go. A Journal of the Social Imaginary, 2017
The defeat of language. The impossibility of telling the Evil: W ou le souvenir d'enfance. Georges Perec's novel W ou le souvenir d'enfance is the result of the fight made by the writer to tell the Evil of his life, the blank left by the tragic loss of ...
Matteo Moca
doaj  

JOURNAL OF L A T E X CLASS FILES, VOL. 1, NO. 11, NOVEMBER 2002 1 How to Use the IEEEtran L [PDF]

open access: yes, 2004
This article describes how to use the IEEEtran class with L T E X to produce high quality typeset papers that are suitable for submission to the Institute of Electrical and Electronics Engineers (IEEE).
Class Michael Shell
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

‘A Class Apart’?: South Asian Immigrants and the White Working Class Left, Yorkshire 1960-1981 [PDF]

open access: yes, 2011
During the 1960s many thousands of South Asian immigrants arrived in the United Kingdom. At first they were, by and large, economic migrants looking to fill British labour shortages and send remittances back home.
Swift, David
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

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