Results 131 to 140 of about 38,654,738 (261)

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

PROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima, Wilson Dias Segura, Leonardo Brogliato de Moraes, Reinaldo Souza Oliveira, Pedro Henrique Corteletti Manfio, Alison Felipe Alencar Chaves, Wagner Luiz Batista   +6 more
wiley   +1 more source

Class IA phosphatidylinositol 3 -kinase involvement in cytoskeletal regulation

, 2002
Phosphoinositide 3-kinases (PI 3-kinases) phosphorylate the D3 position on the inositol ring of phosphatidylinositol. PI 3-kinases products act as second messengers in many different signaling events.
Hill, Karen Marie
core  

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Integrated multi‐omics analysis of post‐translational modifications in head and neck squamous cell carcinoma: elucidating x‐ray and carbon ion irradiation effects

Precision Radiation Oncology, EarlyView.
This study underscores the critical role of PTMs in mediating cellular responses to X‐ray and Carbon ion irradiation radiotherapy in HNSCC. The integration of multi‐omics data provides insights into the molecular mechanisms underlying radiation‐induced changes, offering valuable clues for improving therapeutic outcomes and advancing precision medicine ...
Fan‐Tong Xia, Zhi‐Yun Liao, Si‐Qi Cai, Li‐Rong Zhou, Meng‐Qi Yang, Xin Zhang, Dan Li, Huan Zhang, Yun‐Chang Liu, Jie‐Ying Yang, Jia Jiang, Yi‐Hong Hu, Jiang‐Dong Sui, Ying Wang   +13 more
wiley   +1 more source

Molecular Interactions of Viral Insulin/IGF‐Like Peptides With Zebrafish Receptors

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Signaling through the insulin receptor (IR) and the type 1 insulin‐like growth factor receptor (IGF1R) is modulated by secreted hormones and growth factor ligands (e.g., insulin and insulin‐like growth factor 1, IGF1). Impaired signaling in these receptors often leads to diabetes and oncogenic diseases.
Lev Levintov, Harish Vashisth
wiley   +1 more source

Mechanism of substrate specificity and insights into activation of phosphatidylinositol phosphate kinases

, 2016
The phosphatidylinositol phosphate kinase family of enzymes is primarily responsible for converting singly phosphorylated phosphatidylinositol derivatives to phosphatidylinositol bisphosphates.
Muftuoglu, Yagmur
core  

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Salvianolic Acid C Protects Against Hepatic Ischemia–Reperfusion Injury via Heat Shock Protein 90α‐Mediated Activation of the Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling Pathway

Phytotherapy Research, EarlyView.
Salvianolic acid C (SaC) protects against hepatic ischemia–reperfusion injury (HIRI) by upregulating HSP90α and activating the PI3K/AKT pathway, thereby alleviating oxidative stress, inflammation, apoptosis, and necrosis. ABSTRACT Hepatic ischemia–reperfusion injury (HIRI) is a major challenge in liver surgery, and effective pharmacological ...
Pingping Qiao, Alimu Tulahong, Xinlu Xu, Tiemin Jiang, Ruiqing Zhang, Yanze Lin, Zhongdian Yuan, Rexiati Ruze, Yingmei Shao   +8 more
wiley   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source