Phylogeny of Tec Family Kinases: Identification of a Pre-Metazoan Origin of Btk, Bmx, Itk, Tec, Txk and the Btk Regulator SH3BP5 [PDF]
, 2008 It is generally considered mammals and birds have five Tec family kinases (TFKs): Btk, Bmx (also known as Etk), Itk, Tec, and Txk (also known as Rlk). Here, we discuss the domains and their functions and regulation in TFKs.
Ortutay, Csaba +3 more
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Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]
, 2003 Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Krishnan, S. +3 more
core +8 more sources
Frontiers in Immunology, 2018 The signaling lipid phosphatidylinositol 3,4,5, trisphosphate (PIP3) is an essential mediator of many vital cellular processes, including growth, survival, and metabolism.
Gillian L. Dornan, John E. Burke
doaj +1 more source
Targeting lipid signalling in cancer [PDF]
, 2010 Phosphoinositide 3-kinases (PI3Ks) play an important role in a variety of cellular activities, including mitogenic signalling and cell survival, cytoskeletal remodelling, metabolic control, proliferation and vesicular trafficking.
Cmiljanović, Vladimir
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SnRK2 Protein Kinases-Key Regulators of Plant Response to Abiotic Stresses [PDF]
, 2011 The SnRK2 family members are plant-specific serine/threonine kinases involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development.
Wawer, Izabela +9 more
core +2 more sources
Journal of the Formosan Medical Association, 2019 Purpose: Metaplastic carcinoma of the breast (MCB) is a rare cancer characterized by the histologic presence of two or more histological cell types originating from epithelial and mesenchymal stem cells.
Ming-Han Yang, I-Chun Chen, Yen-Shen Lu
doaj +1 more source
Phosphatidylinositol-3-Kinase Regulates Scavenger Receptor Class B Type I Subcellular Localization and Selective Lipid Uptake in Hepatocytes [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2006 Objective— The high-density lipoprotein (HDL) receptor scavenger receptor Class B type I (SR-BI) plays a key role in mediating the final step of reverse cholesterol transport. This study examined the possible regulation of hepatic SR-BI by phosphatidylinositol-3-kinase (PI3K), a well known regulator ...
Shoba, Shetty +3 more
openaire +2 more sources
The CC Chemokine Monocyte Chemotactic Peptide-1 Activates both the Class I p85/p110 Phosphatidylinositol 3-Kinase and the Class II PI3K-C2α [PDF]
Journal of Biological Chemistry, 1998 The cellular effects of MCP-1 are mediated primarily by binding to CC chemokine receptor-2. We report here that MCP-1 stimulates the formation of the lipid products of phosphatidylinositol (PI) 3-kinase, namely phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PI 3,4,5-P3) in THP-1 cells that can be inhibited by ...
S J, Turner +4 more
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Syk-mediated translocation of PI3Kδ to the leading edge controls lamellipodium formation and migration of leukocytes [PDF]
, 2007 The non-receptor tyrosine kinase Syk is mainly expressed in the hematopoietic system and plays an essential role in β2 integrin-mediated leukocyte activation.
Jakus, Zoltán +18 more
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Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides
Frontiers in Immunology, 2018 One of the most paramount receptor-induced signal transduction mechanisms in hematopoietic cells is production of the lipid second messenger phosphatidylinositol(3,4,5)trisphosphate (PIP3) by class I phosphoinositide 3 kinases (PI3K).
Mila Elich, Karsten Sauer, Karsten Sauer
doaj +1 more source