Results 51 to 60 of about 527,011 (237)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Assessing feature selection method performance with class imbalance data
Machine Learning with Applications, 2021 Identifying the most informative features is a crucial step in feature selection. This paper focuses primarily on wrapper feature selection methods designed to detect important features with F1-score as the target metric. As an initial step, most wrapper
Surani Matharaarachchi +2 more
doaj +1 more source
, 2016 Increasing the spin imbalance in superconductors can spatially modulate the gap by forming Cooper pairs with finite momentum. For large imbalances compared to the Fermi energy, the inhomogeneous FFLO superconductor ultimately becomes a normal metal ...
Piazza, Francesco +2 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Emerging SMOTE and GAN Variants for Data Augmentation in Imbalance Machine Learning Tasks: A Review
IEEE AccessClass imbalance is a pervasive challenge in real-world machine learning (ML) applications, where the minority class, often the class of interest, is significantly underrepresented.
Amadi G. Udu +5 more
doaj +1 more source
Yule-generated trees constrained by node imbalance
, 2013 The Yule process generates a class of binary trees which is fundamental to population genetic models and other applications in evolutionary biology.
Disanto, Filippo +2 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Ensemble-SMOTE: Mitigating Class Imbalance in Graduate on Time Detection
Journal of Informatics and Web EngineeringIn education, detecting students graduating on time is difficult due to high data complexity. Researchers have employed various approaches in identifying on-time graduation with Machine Learning, but it remains a challenging task due to the class ...
Theng-Jia Law +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source