Results 121 to 130 of about 4,707,750 (299)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
On domination numbers of zero-divisor graphs of commutative rings
Electronic Journal of Graph Theory and ApplicationsZero-divisor graphs of a commutative ring R, denoted Γ(R), are well-represented in the literature. In this paper, we consider domination numbers of zero-divisor graphs. For reduced rings, Vatandoost and Ramezani characterized the possible graphs for Γ(R)
Sarah E. Anderson +3 more
doaj +1 more source
Electron. Notes Discret. Math., 2009 In this article, we define a new class of graphs, the fat-extended P4 -laden graphs, and we show a polynomial time algorithm to determine the Grundy number of the graphs in this class. This result implies that the Grundy number can be found in polynomial time for any graph of the following classes: P4 -reducible, extended P4 -reducible, P4 -sparse ...
Júlio César Silva Araújo +1 more
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The Economic Basis of Social Class [PDF]
In this paper we adopt a theory of class positions based on employment relations to assess what implications individuals¿ class positions have for their economic life.
Abigail McKnight, John H Goldthorpe
core
Journal of Number Theory, 1972 AbstractBy means of the large sieve it is proved that ∑n⩽ϰ hα(−n) = ϑ(α) ϰ(α+2)2 + O(ϰ(α+2)2 − (14+ϵ) holds for every α > 0 and ϵ > 0 (h(−n) is the number of classes of primitive quadratic forms with discriminant −n).Some applications of the large sieve to certain multiplicative functions are announced.
openaire +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source