Results 101 to 110 of about 1,371,090 (265)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

An employee empowerment model in healthcare organizations: a case study of the Iranian social security organization

Social Determinants of Health
Background: Employee empowerment in healthcare organizations, which refers to providing staff with the autonomy, authority, and confidence to make decisions and take initiative in their roles, plays a crucial role in enhancing both productivity and the ...
Ali Sadeghinezhad , Hamdollah Manzari Tavakoli, Saeed Sayadi , Mahdi Mohammad Bagheri , Mohammad Jalal Kamali   +4 more
doaj   +1 more source

The automorphism group of a class of semi-groups

Monatshefte f�r Mathematik, 1977
Let (S,·) be a semi-group having the following properties: (1)S=∪Sα where α is in some index setI andSα are subgroups isomorphic to each other, (2)Sα∩Sβ=O, a void set for α≠β and (3) the identity ofSα is a left identity ofS for each α inI. Then the automorphism group Aut (S) ofS is studied from the point of category theory. It is proved that Aut (S) is
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Food group intake trends in the Spanish population (2003–2023) in women and men and by age groups, country of origin, and social class: a time-series analysis of nationally representative surveys

Nutrition Journal
Background We analyzed the intake evolution of 14 food groups (vegetables, fruits, legumes, bread/flours and breakfast cereals, pasta/rice and potatoes, fish, unprocessed meat, processed meat, dairy products, eggs, sweets, snacks, soft drinks, and fresh ...
Sofía Boter, Elena Carrillo-Álvarez, Marta H. Hernández, Camille Lassale, Sara Castro-Barquero, Karla Alejandra Pérez-Vega, Olga Castañer, Alexios Manidis, Viviana Sandoval, María Dolores Zomeño, Blanca Salinas-Roca, Begoña Caneda-Ferrón, Alícia Orta-Ramírez, Joel Montané, Miriam Rodríguez-Monforte, Raimon Milà, Eulàlia Vidal-García, Pilar Gascón, Conxita Mestres, Imma Palma-Linares, Montserrat Fitó, Álvaro Hernáez   +21 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Invariant part of class groups and distribution of relative class group

Journal of Number Theory
We generalize the work of Roquette and Zassenhaus on the invariant part of the class groups to the relative class groups. Thereby, we can show some statistical results as follows. For abelian extensions over a fixed number field K, we show infinite Cp-moments for the Sylow p-subgroup of the relative class group when p divides the degree of the ...
openaire   +3 more sources