Results 141 to 150 of about 174,866,847 (300)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
MUSC College of Medicine Class of 1991
, 1991 MUSC College of Medicine Class of ...
MUSC College of Medicine
core
Villanova University School of Law Commencement Program - Class of 2002 [PDF]
, 2001 The Program for the Commencement Exercises of the 47th graduating class of the Villanova University School of Law in ...
2001, Class of +3 more
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
MUSC College of Medicine Class of 1974
, 1974 MUSC College of Medicine Class of ...
MUSC College of Medicine
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Latent class analysis of symptom groups of patients with colorectal cancer undergoing chemotherapy
Huli yanjiuObjectiveTo identify subgroups of symptoms in patients with colorectal cancer undergoing chemotherapy，and to explore the risk factors for patients with high symptom burdens.MethodsA total of 234 patients with colorectal cancer undergoing chemotherapy ...
ZENG Mengting +3 more
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
MUSC College of Medicine Class of 1980
, 1980 MUSC College of Medicine Class of ...
MUSC College of Medicine
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source