Results 181 to 190 of about 1,371,090 (265)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Syndemic Classes of Unhealthy Alcohol Use Reveal Inequities in Alcohol-Related Consequences and HIV Care Outcomes. [PDF]

Alcohol Clin Exp Res (Hoboken)
Van Doren N, Silverberg MJ, Sarovar V, Levine T, Lea A, Sterling SA, Palzes VA, Chi FW, Kline-Simon AH, Mian MN, Cyrus E, Duthely LM, Dyer T, M Heads A, Horberg M, Tsoh JY, Satre DD.   +16 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Letter to the editor. Re: "Coconut (Cocos nucifera) tree disease dataset: A dataset for disease detection and classification for machine learning applications," Data in Brief, vol. 51, p. 109690, 2023. [PDF]

Data Brief
Sabrigiriraj M, Manoharan K.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Toward AI-Assisted Precision Diagnostics in Breast Cancer: Source-Group-Preserving Evaluation of Class-Imbalance Strategies for Ordered ER-IHC Segmentation. [PDF]

Diagnostics (Basel)
Arefin MS, Islam MS, Nabi MS, Sumon RI, Lapina M, Lapin V, Muthanna M.   +6 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Care network types and depression among people with cognitive impairment: A latent class analysis. [PDF]

PLoS One
Hwang M, Hwang Y.
europepmc   +1 more source